Evidence map›Paper›PMID 34553687›Full record

ArticleeLife2021

Common host variation drives malaria parasite fitness in healthy human red cells.

Emily R Ebel, Frans A Kuypers, Carrie Lin, Dmitri A Petrov, Elizabeth S Egan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Blood group antigens and malaria susceptibility.Frontiers in cellular and infection microbiology · 2025
    Review
  7. Article
  8. Article
  9. Local genetic adaptation to habitat in wild chimpanzees.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Cultivation of Asexual Intraerythrocytic Stages ofPathogens (Basel, Switzerland) · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Emily R EbelDepartment of Biology, Stanford University, Stanford, United States.ORCID 0000-0002-3244-4250
Frans A KuypersChildren's Hospital Oakland Research Institute, Oakland, United States.
Carrie LinDepartment of Pediatrics, Stanford University School of Medicine, Stanford, United States.
Dmitri A PetrovDepartment of Biology, Stanford University, Stanford, United States.ORCID 0000-0002-3664-9130
Elizabeth S EganDepartment of Pediatrics, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-2112-7700
Stanford University · US

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Genomics of rapid adaptation in the lab and in the wildR35GM118165 · NIGMS · STANFORD UNIVERSITY · PI Dmitri Petrov · 2016 to 2026
$8.3M
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142NIGMS NIH HHS R35 GM118165
6 · The paper itself

Abstract

The replication of

Indexed as

AfricaAllelesBlack or African AmericanErythrocytesExome SequencingGenotypeHemoglobin, SickleHumansMalaria, FalciparumPlasmodium falciparumWhite PeopleHemoglobin, Sickleevolutionary biologyhumaninfectious diseasemalariamicrobiologynatural variationparasite fitnessP. falciparumPlasmodium falciparumred blood cells

Identifiers

PMID34553687
PMCPMC8497061
OpenAlexW3200318479

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.