Evidence map›Paper›PMID 34557550›Full record

ReviewBioMed research international2021

Targeting Inflammatory Cytokines to Improve Type 2 Diabetes Control.

Tsvetelina V Velikova, Plamena P Kabakchieva, Yavor S Assyov, Tsvetoslav А Georgiev

Abstract readReview
In one paragraph

Review in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
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  8. Deep Learning-Based Adrenal Gland Volumetry for the Prediction of Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2025
    Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Advancements in diabetes research and stem cell therapy: a concise review.Journal of diabetes and metabolic disorders · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tsvetelina V VelikovaDepartment of Clinical Immunology, University Hospital "Lozenetz", Sofia University "St. Kliment Ohridski", Sofia 1407, Bulgaria.ORCID https://orcid.org/0000-0002-0593-1272
Plamena P KabakchievaClinic of Endocrinology, University Hospital "Alexandrovska, " Department of Internal Medicine, Medical Faculty, Medical University of Sofia, Sofia 1431, Bulgaria.ORCID https://orcid.org/0000-0003-3577-0577
Yavor S AssyovClinic of Endocrinology, University Hospital "Alexandrovska, " Department of Internal Medicine, Medical Faculty, Medical University of Sofia, Sofia 1431, Bulgaria.ORCID https://orcid.org/0000-0002-6195-7346
Tsvetoslav А GeorgievClinic of Rheumatology, University Hospital "St. Marina, " First Department of Internal Medicine, Medical Faculty, Medical University-Varna, Varna 9010, Bulgaria.ORCID https://orcid.org/0000-0002-1652-4648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes (T2D) is one of the most common chronic metabolic disorders in adulthood worldwide, whose pathophysiology includes an abnormal immune response accompanied by cytokine dysregulation and inflammation. As the T2D-related inflammation and its progression were associated with the balance between pro and anti-inflammatory cytokines, anticytokine treatments might represent an additional therapeutic option for T2D patients. This review focuses on existing evidence for antihyperglycemic properties of disease-modifying antirheumatic drugs (DMARDs) and anticytokine agents (anti-TNF-

Indexed as

Clinical Trials as TopicCytokinesDiabetes Mellitus, Type 2HumansInflammation MediatorsModels, BiologicalCytokinesInflammation Mediators

Identifiers

PMID34557550
PMCPMC8455209

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.