Evidence map›Paper›PMID 34559552›Full record

ArticleScience immunology2021

Human cytomegalovirus expands a CD8

Rosa Sottile, M Kazim Panjwani, Colleen M Lau, Anthony F Daniyan, Kento Tanaka, Juliet N Barker, Renier J Brentjens, Joseph C Sun, Jean-Benoît Le Luduec, Katharine C Hsu

Abstract read
In one paragraph

Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Trial
  2. Article
  3. NK-like and networked CD8bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Cancer viroimmunotherapy platforms based on varicella-zoster virus and cytomegalovirus.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Essential role of CD56Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  12. Article
  13. BNT162b2 COVID-19 vaccination elicits the expansion of CD16The Journal of allergy and clinical immunology · 2025
    Article
  14. Article
  15. Article
  16. A vaccine against cytomegalovirus: how close are we?The Journal of clinical investigation · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rosa SottileImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-2950-9508
M Kazim PanjwaniImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-2305-1164
Colleen M LauImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-7538-094X
Anthony F DaniyanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kento TanakaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-8513-7748
Juliet N BarkerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-6693-0911
Renier J BrentjensDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-3364-5388
Joseph C SunImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-8062-9033
Jean-Benoît Le LuduecImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Katharine C HsuImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-2827-5324

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Hematopopietic Stem Cell TransplantationU01AI069197 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Effie W Petersdorf · 2005 to 2026
$18.9M
HCMV-induced innate-like CD8 T cells and allogeneic HCT outcomeR01AI150999 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HSU, KATHARINE C · 2021 to 2025
$3.6M
Machine learning with immunogenetics for the prediction of hematopoietic cell transplant outcomesR01HL155741 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI HSU, KATHARINE C · 2021 to 2024
$2.4M
NCI NIH HHS P30 CA008748NHLBI NIH HHS R01 HL155741NIAID NIH HHS R01 AI150999NIAID NIH HHS U01 AI069197
6 · The paper itself

Abstract

CD8

Indexed as

CD8-Positive T-LymphocytesCytomegalovirusHumansKiller Cells, NaturalRepressor ProteinsTumor Cells, CulturedTumor Suppressor ProteinsBCL11B protein, humanRepressor ProteinsTumor Suppressor Proteins

Identifiers

PMID34559552
PMCPMC8601152

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.