ReviewToxics2021
Mechanisms of Neurotoxicity Associated with Exposure to the Herbicide Atrazine.
Review in Toxics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- Atrazine alters kisspeptin signaling and downstream neuroendocrine regulation following embryonic exposure in zebrafish.Toxicology · 2026Article
- Molecular basis of Arabidopsis ABCC2 in plant detoxification.Cell discovery · 2026Article
- Gestational and Lactational Atrazine Exposure Potentially Mediates Behavioral and Dopaminergic Alterations in Rat Offspring: Insights into Nurr1-Related ceRNA Regulation.International journal of molecular sciences · 2026Article
- Bacterial Biomass-based Remediation of Atrazine and Terbuthylazine- A Review on Pathways, Operating Conditions, and Toxicology.Current microbiology · 2026Review
- Endogenous and environmental factors that induce DNA replication defects and genomic instability in ER-negative heterozygous BRCA1 cells.Scientific reports · 2026Article
- High pesticide exposure events and subjective cognitive complaints among US farmers.Environmental research · 2026Article
- Review
- Therapeutic role of plant bioactive compounds in atrazine-mediated neurotoxicity.Advances in neurotoxicology · 2026Article
- An In Vivo and In Silico Experimental Approach on Rats' Neurobehaviour upon Treatment with Atrazine and Manganese.Molecular neurobiology · 2025Article
- Xenobiotic Toxicants and Particulate Matter: Effects, Mechanisms, Impacts on Human Health, and Mitigation Strategies.Journal of xenobiotics · 2025Review
- Impact of Atrazine on Sucrose Sensitivity in Honey Bees.Insects · 2025Article
- [Open experiment: QuEChERS combined with fluorescence derivatization for the detection of atrazine and its effect on enzyme activity].Se pu = Chinese journal of chromatography · 2025Article
- Sex, not yeast or atrazine concentration, affects virgin adultmicroPublication biology · 2025Article
- Children's exposure to herbicides in Jalisco, Mexico-a public health concern perspective.Frontiers in public health · 2025Article
- Integrated Analysis of Neuroendocrine and Neurotransmission Pathways Following Developmental Atrazine Exposure in Zebrafish.International journal of molecular sciences · 2024Article
- Low-tech innovation: biomimetic solid-contact potentiometric sensor for nanomolar-level atrazine detection.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- A review on toxic effects of pesticides in Zebrafish,Toxicology reports · 2024Review
- Article
- Laccase Immobilized on Arginine-Functionalized Boron Nitride Nanosheets for Enhanced Atrazine Degradation.Environmental science & technology · 2024Article
- A New Insight into the Mechanism of Atrazine-Induced Neurotoxicity: Triggering Neural Stem Cell Senescence by Activating the Integrated Stress Response Pathway.Research (Washington, D.C.) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Atrazine is an herbicide commonly used on crops to prevent broadleaf weeds. Atrazine is an endocrine-disrupting chemical mainly targeting the neuroendocrine system and associated axes, especially as a reproductive toxicant through attenuation of the luteinizing hormone (LH). Current regulatory levels for chronic exposure are based on no observed adverse effect levels (NOAELs) of these LH alterations in rodent studies. Atrazine has also been studied for its effects on the central nervous system and neurotransmission. The European Union (EU) recognized the health risks of atrazine exposure as a public health concern with no way to contain contamination of drinking water. As such, the EU banned atrazine use in 2003. The United States recently reapproved atrazine's use in the fall of 2020. Research has shown that there is a wide array of adverse health effects that are seen across multiple models, exposure times, and exposure periods leading to dysfunction in many different systems in the body with most pointing to a neuroendocrine target of toxicity. There is evidence of crosstalk between systems that can be affected by atrazine exposure, causing widespread dysfunction and leading to changes in behavior even with no direct link to the hypothalamus. The hypothetical mechanism of toxicity of atrazine endocrine disruption and neurotoxicity can therefore be described as a web of pathways that are influenced through changes occurring in each and their multiple feedback loops with further research needed to refine NOAELs for neurotoxic outcomes.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.