Evidence map›Paper›PMID 34565656›Full record

ReviewTrends in endocrinology and metabolism: TEM2021

From benzodiazepines to fatty acids and beyond: revisiting the role of ACBP/DBI.

Thierry Alquier, Catherine A Christian-Hinman, Julieta Alfonso, Nils J Færgeman

Open access · greenAbstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Biomedicines · 2025
    Article
  6. Article
  7. Article
  8. DBI Mediates the Progression of Ankylosing Spondylitis by Regulating CD56Analytical cellular pathology (Amsterdam) · 2025
    Article
  9. Article
  10. Article
  11. Obesity-Associated Colorectal Cancer.International journal of molecular sciences · 2024
    Review
  12. Transcriptome analysis of adipose tissue and muscle of Laiwu and Duroc pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Thierry AlquierCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal Diabetes Research Center, and Departments of Medicine, Pharmacology and Physiology, Biochemistry, and Neurosciences, Université de Montréal, Montreal, QC, Canada. Electronic address: thierry.alquier@umontreal.ca.
Catherine A Christian-HinmanDepartment of Molecular and Integrative Physiology, Neuroscience Program, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Julieta AlfonsoDepartment of Clinical Neurobiology, University Hospital Heidelberg and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Nils J FærgemanDepartment of Biochemistry and Molecular Biology, Villum Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark. Electronic address: nils.f@bmb.sdu.dk.
Centre Hospitalier de l’Université de Montréal · CAGerman Cancer Research Center · DEUniversity of Illinois Urbana-Champaign · USUniversity of Southern Denmark · DK

Funding

Neural and pituitary mechanisms linking epilepsy to co-morbid reproductive endocrine dysfunctionR01NS105825 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHRISTIAN-HINMAN, CATHERINE A · 2018 to 2022
$1.8M
CIHR PJT153035NINDS NIH HHS R01 NS105825
6 · The paper itself

Abstract

Four decades ago Costa and colleagues identified a small, secreted polypeptide in the brain that can displace the benzodiazepine diazepam from the GABA

Indexed as

BenzodiazepinesFatty AcidsAnimalsDiazepam Binding InhibitorHumansMammalsBenzodiazepinesDiazepam Binding InhibitorFatty Acidsacyl-CoAacyl-CoA binding protein (ACBP)diazepam binding inhibitor (DBI)fatty acid metabolismGABA(A) receptorGPCR

Identifiers

PMID34565656
PMCPMC8785413
OpenAlexW3204922674

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.