Evidence map›Paper›PMID 34566955›Full record

ReviewFrontiers in immunology2021

Minimizing Ischemia Reperfusion Injury in Xenotransplantation.

Parth M Patel, Margaret R Connolly, Taylor M Coe, Anthony Calhoun, Franziska Pollok, James F Markmann, Lars Burdorf, Agnes Azimzadeh, Joren C Madsen, Richard N Pierson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Review
  5. Article
  6. Mechanism of post cardiac arrest syndrome based on animal models of cardiac arrest.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Failing Heart Transplants and Rejection-A Cellular Perspective.Journal of cardiovascular development and disease · 2021
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Parth M PatelDepartment of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Margaret R ConnollyDepartment of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Taylor M CoeDepartment of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Anthony CalhounDepartment of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Franziska PollokDepartment of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
James F MarkmannDepartment of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Lars BurdorfDepartment of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Agnes AzimzadehDepartment of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Joren C MadsenDepartment of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Richard N PiersonDepartment of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Funding

TRAINING IN TRANSPLANTATION BIOLOGYT32AI007529 · MASSACHUSETTS GENERAL HOSPITAL · 1998 to 2005
$1.8M
NIAID NIH HHS R01 AI153612NIAID NIH HHS T32 AI007529NIAID NIH HHS U01 AI153612
6 · The paper itself

Abstract

The recent dramatic advances in preventing "initial xenograft dysfunction" in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotransplantation. Here we review the molecular, cellular, and immune mechanisms that characterize IRI and associated "primary graft dysfunction" in allotransplantation and consider how they correspond with "xeno-associated" injury mechanisms. Based on this analysis, we describe potential genetic modifications as well as novel technical strategies that may minimize IRI for heart and other organ xenografts and which could facilitate safe and effective clinical xenotransplantation.

Indexed as

Organ TransplantationAdaptive ImmunityAnimalsBiomarkersComplement System ProteinsDisease ManagementDisease SusceptibilityHeterograftsHumansImmunity, InnateMitochondriaOrgan SpecificityOxidative StressReactive Oxygen SpeciesReperfusion InjuryTransplantation, HeterologousBiomarkersComplement System ProteinsReactive Oxygen Speciesex vivo perfusioninitial xenograft dysfunctionischemia reperfusion injury mechanismsischemia reperfusion injury minimizationischemia reperfusion (I/R) injuryxenotranplantation

Identifiers

PMID34566955
PMCPMC8458821

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.