ArticleCells2021
Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse.
Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Lim Homeobox 8 Is Essential for Beta Adrenergic Stimulation of Thermogenesis in Human Adipocytes.Cells · 2026Article
- Targeting perivascular adipose tissue in vascular aging: innovative translational strategies for disease prevention and monitoring.Apoptosis : an international journal on programmed cell death · 2026Review
- Caraway Extract IncreasesInternational journal of molecular sciences · 2025Article
- Adipose Tissue Macrophages of the Human Fetus.Cells · 2024Article
- Key questions and gaps in understanding adipose tissue macrophages and early-life metabolic programming.American journal of physiology. Endocrinology and metabolism · 2024Review
- Article
- Interleukin-6: An Under-Appreciated Inducer of Thermogenic Adipocyte Differentiation.International journal of molecular sciences · 2024Review
- Adipose Tissue Macrophages.Results and problems in cell differentiation · 2024Review
- Article
- Review
- PRDM16 regulates γδT17 cell differentiation via controlling type 17 program and lipid-dependent cell fitness.Frontiers in immunology · 2023Article
- Metabolic impact of adipose tissue macrophages in the early postnatal life.Journal of leukocyte biology · 2022Review
- Brown to White Fat Transition Overlap With Skeletal Muscle During Development of Larger Mammals: Is it a Coincidence?Journal of the Endocrine Society · 2022Review
- Co-Evolution of Breast Milk Lipid Signaling and Thermogenic Adipose Tissue.Biomolecules · 2021Review
- Article
- Origin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The present study sought to identify gene networks that are hallmarks of the developing inguinal subcutaneous adipose tissue (iWAT) and the interscapular brown adipose tissue (BAT) in the mouse. RNA profiling revealed that the iWAT of postnatal (P) day 6 mice expressed thermogenic and lipid catabolism transcripts, along with the abundance of transcripts associated with the beige adipogenesis program. This was an unexpected finding, as thermogenic BAT was believed to be the only site of nonshivering thermogenesis in the young mouse. However, the transcriptional landscape of BAT in P6 mice suggests that it is still undergoing differentiation and maturation, and that the iWAT temporally adopts thermogenic and lipolytic potential. Moreover, P6 iWAT and adult (P56) BAT were similar in their expression of immune gene networks, but P6 iWAT was unique in the abundant expression of antimicrobial proteins and virus entry factors, including a possible receptor for SARS-CoV-2. In summary, postnatal iWAT development is associated with a metabolic shift from thermogenesis and lipolysis towards fat storage. However, transcripts of beige-inducing signal pathways including β-adrenergic receptors and interleukin-4 signaling were underrepresented in young iWAT, suggesting that the signals for thermogenic fat differentiation may be different in early postnatal life and in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.