Evidence map›Paper›PMID 34572265›Full record

ArticleBiomedicines2021

Salivary miR-30c-5p as Potential Biomarker for Detection of Oral Squamous Cell Carcinoma.

Nikolay Mehterov, Boyan Vladimirov, Andrea Sacconi, Claudio Pulito, Marcin Rucinski, Giovanni Blandino, Victoria Sarafian

Abstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Roles of Wnt ligands and receptors in oral squamous cell carcinoma.Journal of Zhejiang University. Science. B · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. MicroRNAs as Biomarkers and Therapeutic Targets in Female Infertility.International journal of molecular sciences · 2024
    Review
  10. Review
  11. Article
  12. International journal of molecular sciences · 2024
    Article
  13. Article
  14. Oral Squamous Cell Carcinoma: Focus on Biomarkers for Screening.Journal of dentistry (Shiraz, Iran) · 2024
    Review
  15. [Advances in salivary exosomal miRNAs in head and neck squamous carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nikolay MehterovDepartment of Medical Biology, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.
Boyan VladimirovDepartment of Maxillofacial Surgery, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.
Andrea SacconiUOSD Clinical Trial Center, Biostatistics and Bioinformatics, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0002-8276-0438
Claudio PulitoOncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0002-0921-6962
Marcin RucinskiDepartment of Histology and Embryology, Poznan University of Medical Sciences, 61-781 Poznan, Poland.ORCID 0000-0002-2525-5777
Giovanni BlandinoOncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Victoria SarafianDepartment of Medical Biology, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.

Funding

Bulgarian National Science Fund КП-06-М23/1Ministry of Education, Youth and Science Project NUCBAS-BBMRI.BG, Contract D01-395/18.12.2020
6 · The paper itself

Abstract

The levels of different classes of extracellular RNAs (exRNAs) remain stable in bodily fluids. The detection of either enriched or depleted specific subsets of salivary microRNAs (miRNAs) has the potential to serve as a non-invasive approach for biomarker development. Thus, salivary miRNAs have emerged as a promising molecular tool for early diagnosis and screening of oral squamous cell carcinoma (OSCC). Total RNA was extracted from saliva supernatant of 33 OSCC patients and 12 controls (discovery set), and the differential expression of 8 cancer-related miRNAs was detected by TaqMan assay. Among the screened miRNAs, miR-30c-5p (

Indexed as

biomarkersmiRNAOSCCsaliva

Identifiers

PMID34572265
PMCPMC8465705

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.