Evidence map›Paper›PMID 34572292›Full record

ReviewBiomedicines2021

H

Francesca Gorini, Serena Del Turco, Laura Sabatino, Melania Gaggini, Cristina Vassalle

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Signaling Paradigms of HAntioxidants (Basel, Switzerland) · 2024
    Review
  9. Review
  10. Utility of NO and HNitric oxide : biology and chemistry · 2022
    Review
  11. Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Francesca GoriniInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.ORCID 0000-0002-4619-6227
Serena Del TurcoInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.ORCID 0000-0003-3722-8861
Laura SabatinoInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.ORCID 0000-0002-9283-5042
Melania GagginiInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
Cristina VassalleFondazione CNR-Regione Toscana G. Monasterio, 56124 Pisa, Italy.ORCID 0000-0003-3438-6450
Istituto di Fisiologia Clinica · ITFondazione Toscana Gabriele Monasterio · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endothelium controls vascular homeostasis through a delicate balance between secretion of vasodilators and vasoconstrictors. The loss of physiological homeostasis leads to endothelial dysfunction, for which inflammatory events represent critical determinants. In this context, therapeutic approaches targeting inflammation-related vascular injury may help for the treatment of cardiovascular disease and a multitude of other conditions related to endothelium dysfunction, including COVID-19. In recent years, within the complexity of the inflammatory scenario related to loss of vessel integrity, hydrogen sulfide (H

Indexed as

COVID-19endotheliumhydrogen sulfideinflammationSARS-CoV-2therapeutic target

Identifiers

PMID34572292
PMCPMC8472626
OpenAlexW3196747430

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.