Evidence map›Paper›PMID 34572974›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme.

Qiuchen Zheng, Micheal T Kebede, Bethany Lee, Claire A Krasinski, Saadman Islam, Liliana A Wurfl, Merc M Kemeh, Valerie A Ivancic, Charles E Jakobsche, Donald E Spratt and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Qiuchen ZhengGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
Micheal T KebedeGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
Bethany LeeGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
Claire A KrasinskiGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
Saadman IslamGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
Liliana A WurflGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
Merc M KemehGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
Valerie A IvancicGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
Charles E JakobscheGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
Donald E SprattGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.ORCID 0000-0002-0699-155X
Noel D LazoGustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.ORCID 0000-0003-1769-7572
Clark University · US

Funding

Structure and Mechanism of HERC5-dependent ISGylationR15GM126432 · NIGMS · CLARK UNIVERSITY (WORCESTER, MA) · PI SPRATT, DONALD ERIC · 2017 to 2023
$1000k
Determinants of the Proteolytic Degradation of Soluble Amyloid-betaR15AG055043 · NIA · CLARK UNIVERSITY (WORCESTER, MA) · PI LAZO, NOEL D. · 2018 to 2018
$376k
NIA NIH HHS R15 AG055043NIA NIH HHS R15AG055043NIGMS NIH HHS R15 GM126432
6 · The paper itself

Abstract

The insulin-degrading enzyme (IDE) possesses a strong ability to degrade insulin and Aβ42 that has been linked to the neurodegeneration in Alzheimer's disease (AD). Given this, an attractive IDE-centric strategy for the development of therapeutics for AD is to boost IDE's activity for the clearance of Aβ42 without offsetting insulin proteostasis. Recently, we showed that resveratrol enhances IDE's activity toward Aβ42. In this work, we used a combination of chromatographic and spectroscopic techniques to investigate the effects of resveratrol on IDE's activity toward insulin. For comparison, we also studied epigallocatechin-3-gallate (EGCG). Our results show that the two polyphenols affect the IDE-dependent degradation of insulin in different ways: EGCG inhibits IDE while resveratrol has no effect. These findings suggest that polyphenols provide a path for developing therapeutic strategies that can selectively target IDE substrate specificity.

Indexed as

epigallocatechin-3-gallateinsulin-degrading enzymepolyphenolsresveratrol

Identifiers

PMID34572974
PMCPMC8467823
OpenAlexW3193366463

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.