Evidence map›Paper›PMID 34573024›Full record

ArticleAntioxidants (Basel, Switzerland)2021

The Role of Endoplasmic Reticulum in the Differential Endurance against Redox Stress in Cortical and Spinal Astrocytes from the Newborn SOD1

Cecilia Marini, Vanessa Cossu, Mandeep Kumar, Marco Milanese, Katia Cortese, Silvia Bruno, Grazia Bellese, Sonia Carta, Roberta Arianna Zerbo, Carola Torazza and 11 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Cecilia MariniCNR Institute of Molecular Bioimaging and Physiology (IBFM), Segrate, 20054 Milan, Italy.
Vanessa CossuDepartment of Health Sciences, University of Genoa, 16132 Genoa, Italy.
Mandeep KumarDepartment of Pharmacy, Section of Pharmacology and Toxicology, University of Genoa, 16148 Genoa, Italy.
Marco MilaneseDepartment of Pharmacy, Section of Pharmacology and Toxicology, University of Genoa, 16148 Genoa, Italy.
Katia CorteseDepartment of Experimental Medicine, Human Anatomy, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0001-9218-8933
Silvia BrunoDepartment of Experimental Medicine, Human Anatomy, University of Genoa, 16132 Genoa, Italy.
Grazia BelleseDepartment of Experimental Medicine, Human Anatomy, University of Genoa, 16132 Genoa, Italy.
Sonia CartaCell Biology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Roberta Arianna ZerboDepartment of Pharmacy, Section of Pharmacology and Toxicology, University of Genoa, 16148 Genoa, Italy.
Carola TorazzaDepartment of Pharmacy, Section of Pharmacology and Toxicology, University of Genoa, 16148 Genoa, Italy.
Matteo BaucknehtNuclear Medicine, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0002-1937-9116
Consuelo VenturiDepartment of Experimental Medicine, Human Anatomy, University of Genoa, 16132 Genoa, Italy.
Stefano RaffaDepartment of Health Sciences, University of Genoa, 16132 Genoa, Italy.
Anna Maria OrengoNuclear Medicine, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Maria Isabella DoneganiDepartment of Health Sciences, University of Genoa, 16132 Genoa, Italy.
Silvia ChiolaNuclear Medicine, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Silvia RaveraDepartment of Experimental Medicine, Human Anatomy, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-0803-1042
Patrizia CastellaniCell Biology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Silvia MorbelliNuclear Medicine, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Gianmario SambucetiCNR Institute of Molecular Bioimaging and Physiology (IBFM), Segrate, 20054 Milan, Italy.ORCID 0000-0003-2979-6500
Giambattista BonannoDepartment of Pharmacy, Section of Pharmacology and Toxicology, University of Genoa, 16148 Genoa, Italy.ORCID 0000-0003-3744-5786
University of Genoa · ITOspedale Policlinico San Martino · ITInstitute of Molecular Bioimaging and Physiology · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG 23201Compagnia di San Paolo 2015.AAI4110.U4917
6 · The paper itself

Abstract

Recent studies reported that the uptake of [18F]-fluorodeoxyglucose (FDG) is increased in the spinal cord (SC) and decreased in the motor cortex (MC) of patients with ALS, suggesting that the disease might differently affect the two nervous districts with different time sequence or with different mechanisms. Here we show that MC and SC astrocytes harvested from newborn B6SJL-Tg (SOD1

Indexed as

Amyotrophic Lateral Sclerosis (ALS)astrocytesendoplasmic reticulumFDG-PET/CTH6PDmotor cortexpentose phosphate pathwayredox stressSOD1G93Aspinal cord

Identifiers

PMID34573024
PMCPMC8472526
OpenAlexW3196850494

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.