Evidence map›Paper›PMID 34573054›Full record

ArticleAntioxidants (Basel, Switzerland)2021

The Effect of Oxidative Stress on the Chicken Ovary: Involvement of Microbiota and Melatonin Interventions.

Jianping Wang, Ru Jia, Haojie Gong, Pietro Celi, Yong Zhuo, Xuemei Ding, Shiping Bai, Qiufeng Zeng, Huadong Yin, Shengyu Xu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 67 citations in OpenAlex.

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  16. Benzoic Acid,Animals : an open access journal from MDPI · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jianping WangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0002-6596-8771
Ru JiaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Haojie GongAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Pietro CeliFaculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville 3010, Australia.
Yong ZhuoAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0002-8348-4199
Xuemei DingAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Shiping BaiAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0002-5775-1900
Qiufeng ZengAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Huadong YinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0001-9132-3603
Shengyu XuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Jingbo LiuSchool of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.
Xiangbing MaoAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0002-6292-7747
Keying ZhangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.ORCID 0000-0002-2909-3357
Sichuan Agricultural University · CNSouthwest University of Science and Technology · CNThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The poultry ovary is used as a classic model to study ovarian biology and ovarian cancer. Stress factors induced oxidative stress to cause follicle atresia, which may be a fundamental reason for the reduction in fertility in older laying hens or in aging women. In the present study, we set out to characterize the relationships between oxidative stress and ovarian function. Layers (62 weeks of age; BW = 1.42 ± 0.12 kg) were injected with tert-butyl hydroperoxide (tBHP) at 0 (CON) and 800 μmol/kg BW (oxidative stress group, OS) for 24 days and the role of melatonin (Mel) on tBHP-induced ovary oxidative stress was assessed through ovary culture in vitro. The OS (800 μmol/kg BW tert-butyl hydroperoxide) treatment decreased the reproduction performance and ovarian follicle numbers. OS decreased the expression of SIRT1 and increased the

Indexed as

cecal microbiotafollicle atresiamelatoninmetabolomicsovary stress biomarkerSIRT1-P53/FoxO1 pathway

Identifiers

PMID34573054
PMCPMC8472688
OpenAlexW3197819978

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.