Evidence map›Paper›PMID 34573335›Full record

ReviewGenes2021

Targeting the CDK6 Dependence of Ph+ Acute Lymphoblastic Leukemia.

Patrizia Porazzi, Marco De Dominici, Joseph Salvino, Bruno Calabretta

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Patrizia PorazziDepartment of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-1372-7482
Marco De DominiciDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Joseph SalvinoThe Wistar Institute, Philadelphia, PA 19104, USA.ORCID 0000-0002-2184-5980
Bruno CalabrettaDepartment of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Thomas Jefferson University · USThe Wistar Institute · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Targeting CDK6 expression/activity in Ph+ and Ph1-like acute lymphoblastic leukemia (ALL)R01CA257251 · NCI · THOMAS JEFFERSON UNIVERSITY · PI CALABRETTA, BRUNO, SALVINO, JOSEPH M · 2021 to 2025
$3.1M
NIH HHS R01-HL127895
6 · The paper itself

Abstract

Ph+ ALL is a poor-prognosis leukemia subtype driven by the

Indexed as

Cyclin-Dependent Kinase 6Antineoplastic AgentsFusion Proteins, bcr-ablGene Expression Regulation, LeukemicHumansMolecular Targeted TherapyPrecursor Cell Lymphoblastic Leukemia-LymphomaProtein Kinase InhibitorsProto-Oncogene Proteins c-mybAntineoplastic AgentsCDK6 protein, humanCyclin-Dependent Kinase 6Fusion Proteins, bcr-ablMYB protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins c-mybapoptosiscell cyclechemotherapykinaseproteolysis-targeting chimeras (PROTACs)

Identifiers

PMID34573335
PMCPMC8467343
OpenAlexW3196755890

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.