Evidence map›Paper›PMID 34573378›Full record

ArticleGenes2021

Selective Breeding for Disease-Resistant

Nicholas Haley, Rozalyn Donner, Kahla Merrett, Matthew Miller, Kristen Senior

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Old nodes, new tricks: optimized methods for chronic wasting disease prion detection in preserved retropharyngeal lymph nodes.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2026
    Article
  3. Novel Prion Protein Gene (bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
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  12. Article
  13. Article
  14. Article
  15. Large animal models for chronic wasting disease.Cell and tissue research · 2023
    Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicholas HaleyDepartment of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ 85331, USA.ORCID 0000-0003-0502-7862
Rozalyn DonnerDepartment of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ 85331, USA.
Kahla MerrettDepartment of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ 85331, USA.
Matthew MillerDepartment of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ 85331, USA.
Kristen SeniorDepartment of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ 85331, USA.
Midwestern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy (TSE) of cervids caused by a misfolded variant of the normal cellular prion protein, and it is closely related to sheep scrapie. Variations in a host's prion gene,

Indexed as

Selective BreedingAgricultureAnimalsDeerDisease ResistanceFarmsFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesImmunity, HerdMalePolymorphism, Single NucleotidePrion DiseasesPrion ProteinsPrion ProteinsCWDdeerprionPRNPresistanceselective breedingsusceptibility

Identifiers

PMID34573378
PMCPMC8471411
OpenAlexW3201144278

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.