ArticleAnimals : an open access journal from MDPI2021
Detection and Visualization of Heterozygosity-Rich Regions and Runs of Homozygosity in Worldwide Sheep Populations.
Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Genome-wide comparison of traditional and commercial Mehraban sheep populations reveals differences in genetic structure, linkage disequilibrium, and inbreeding patterns.BMC genomics · 2026Article
- Genetic diversity of US Rambouillet in the National Sheep Improvement Program compared to other sheep breeds.The Journal of heredity · 2026Article
- Runs of homozygosity in Italian Holstein bulls: a permutation approach and time-based mapping of the genomic regions potentially under selection.BMC genomics · 2026Article
- Detection of homozygosity and heterozygosity regions in mediterranean sheep breeds revealed by high-density SNP array.Journal of animal science · 2026Article
- Artificial and natural selection components reveal the mechanisms of tropical sheep populations against gastrointestinal parasites.PloS one · 2026Article
- Estimation of genome-wide patterns of homozygosity, heterozygosity and inbreeding in crossbred dairy cattle population in Pakistan.Tropical animal health and production · 2025Article
- Genomic Characterization of the Kazakh Fat-Tailed Coarse-Wool Sheep Breed Using ROH Analysis.Animals : an open access journal from MDPI · 2025Article
- Unravelling Heterozygosity-Rich Regions in the Holstein Genome.Animals : an open access journal from MDPI · 2025Article
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- Heterozygosity-Rich Regions in Canine Genome: Can They Serve as Indicators of Balancing Selection?Animals : an open access journal from MDPI · 2025Article
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- Genetic diversity of United States Rambouillet, Katahdin and Dorper sheep.Genetics, selection, evolution : GSE · 2024Article
- Detection and evaluation of parameters influencing the identification of heterozygous-enriched regions in Holstein cattle based on SNP chip or whole-genome sequence data.BMC genomics · 2024Article
- Effect of genotyping density on the detection of runs of homozygosity and heterozygosity in cattle.Journal of animal science · 2024Article
- Characterization of heterozygosity-rich regions in Italian and worldwide goat breeds.Scientific reports · 2024Article
- Insight into the current genomic diversity, conservation status and population structure of Tunisian Barbarine sheep breed.Frontiers in genetics · 2024Article
- Assessment of genetic diversity and population structure of U.S. Polypay sheep from breed origins to future genomic selection.Frontiers in genetics · 2024Article
- Approaching autozygosity in a small pedigree of Gochu Asturcelta pigs.Genetics, selection, evolution : GSE · 2023Article
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Authors and funding
7 authors.
Funding
Abstract
In this study, we chose 17 worldwide sheep populations of eight breeds, which were intensively selected for different purposes (meat, milk, or wool), or locally-adapted breeds, in order to identify and characterize factors impacting the detection of runs of homozygosity (ROH) and heterozygosity-rich regions (HRRs) in sheep. We also applied a business intelligence (BI) tool to integrate and visualize outputs from complementary analyses. We observed a prevalence of short ROH, and a clear distinction between the ROH profiles across populations. The visualizations showed a fragmentation of medium and long ROH segments. Furthermore, we tested different scenarios for the detection of HRR and evaluated the impact of the detection parameters used. Our findings suggest that HRRs are small and frequent in the sheep genome; however, further studies with higher density SNP chips and different detection methods are suggested for future research. We also defined ROH and HRR islands and identified common regions across the populations, where genes related to a variety of traits were reported, such as body size, muscle development, and brain functions. These results indicate that such regions are associated with many traits, and thus were under selective pressure in sheep breeds raised for different purposes. Interestingly, many candidate genes detected within the HRR islands were associated with brain integrity. We also observed a strong association of high linkage disequilibrium pattern with ROH compared with HRR, despite the fact that many regions in linkage disequilibrium were not located in ROH regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.