ReviewJournal of clinical medicine2021
Potentially Detrimental Effects of Hyperosmolality in Patients Treated for Traumatic Brain Injury.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Comparison of utilizing a hypertonic saline solution and mannitol to improve brain relaxation during craniotomy in patients with brain tumours: a prospective randomized controlled trial.Scientific reports · 2025Trial
- A predictive model for the risk of sepsis within 30 days of admission in patients with traumatic brain injury in the intensive care unit: a retrospective analysis based on MIMIC-IV database.European journal of medical research · 2023Trial
- Electrolyte-derived clinical indices in traumatic brain injury: A narrative review.World journal of methodology · 2026Review
- The U-shaped association between serum osmolality and 28-day mortality in patients with acute respiratory failure: a retrospective cohort study using the MIMIC-IV database.Journal of thoracic disease · 2026Article
- Cardiovascular implications of osmotic changes during hemodialysis: a potential risk factor.International urology and nephrology · 2026Article
- Modeling Spinal Cord Injury in a Dish with Hyperosmotic Stress: Population-Specific Effects and the Modulatory Role of Mesenchymal Stromal Cell Secretome.International journal of molecular sciences · 2025Article
- Mobilization in Neurocritical Care: Challenges and Opportunities.Current neurology and neuroscience reports · 2024Review
- Early Hyperosmolarity and Favorable Outcome in Severe Traumatic Brain Injury? Take it with a Grain of Salt.Neurocritical care · 2024Article
- Should Hypertonic Saline Be Considered for the Treatment of Intracranial Hypertension? A Review of Current Evidence and Clinical Practices.Korean journal of neurotrauma · 2024Review
- Preliminary research on tailored fluid therapy in pigs: comparing customized ionic solutions with Hartmann's solution.BMC veterinary research · 2024Article
- Osmotic Demyelination Syndrome Associated with Uremia and Elevated Serum Osmolality.Neurocritical care · 2024Article
- Osmotic Demyelination Syndrome in the Setting of Normonatremia: A Case Report and Review of the Literature.Case reports in neurological medicine · 2024Article
- Invasive Multimodality Neuromonitoring to Manage Cerebral Edema in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.Critical care explorations · 2023Article
- Alterations to Kidney Physiology during Cardiopulmonary Bypass-A Narrative Review of the Literature and Practical Remarks.Journal of clinical medicine · 2023Review
- Purinergic signaling: A gatekeeper of blood-brain barrier permeation.Frontiers in pharmacology · 2023Review
- Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk Factors.Journal of clinical medicine · 2022Article
- 3D printed devices with integrated collagen scaffolds for cell culture studies including transepithelial/transendothelial electrical resistance (TEER) measurements.Analytica chimica acta · 2022Article
- The Effect of Hypothermia and Osmotic Shock on the Electrocardiogram of Adult Zebrafish.Biology · 2022Article
- Drug Delivery Challenges in Brain Disorders across the Blood-Brain Barrier: Novel Methods and Future Considerations for Improved Therapy.Biomedicines · 2021Review
- Inpatient Metabolic Panel Trajectories Improve 6-Month Mortality Prognostication after Severe Traumatic Brain Injury.Neurotrauma reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperosmotic therapy is commonly used to treat intracranial hypertension in traumatic brain injury patients. Unfortunately, hyperosmolality also affects other organs. An increase in plasma osmolality may impair kidney, cardiac, and immune function, and increase blood-brain barrier permeability. These effects are related not only to the type of hyperosmotic agents, but also to the level of hyperosmolality. The commonly recommended osmolality of 320 mOsm/kg H
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.