Evidence map›Paper›PMID 34575976›Full record

ArticleInternational journal of molecular sciences2021

PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling.

Zelei Yang, Xiaoyun Tang, Todd P W McMullen, David N Brindley, Denise G Hemmings

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zelei YangDepartment of Biochemistry, University of Alberta, Edmonton, AB T6G 2S2, Canada.
Xiaoyun TangDepartment of Biochemistry, University of Alberta, Edmonton, AB T6G 2S2, Canada.
Todd P W McMullenCancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2S2, Canada.
David N BrindleyDepartment of Biochemistry, University of Alberta, Edmonton, AB T6G 2S2, Canada.ORCID 0000-0003-2227-0020
Denise G HemmingsCancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2S2, Canada.
University of Alberta · CA

Funding

Canadian Cancer Society Research Institute 300034CIHR MOP123488CIHR PJT-169140Li Ka Shing Institute of Virology, University of Alberta DG HemmingsWomen and Children's Health Research Institute 01
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) infects 40-70% of adults in developed countries. HCMV proteins and DNA are detected in tumors and metastases, suggesting an association with increased invasion. We investigated HCMV infection in human breast cancer cell lines compared to fibroblasts, a component of tumors, and the role of platelet-derived growth factor receptor-α (PDGFRα). HCMV productively infected HEL299 fibroblasts and, to a lesser extent, Hs578T breast cancer cells. Infection of another triple-negative cell line, MDA-MB-231, and also MCF-7 cells, was extremely low. These disparate infection rates correlated with expression of

Indexed as

Breast NeoplasmsCytomegalovirusCytomegalovirus InfectionsFemaleFibroblastsGene Expression Regulation, NeoplasticHumansLysophospholipidsMCF-7 CellsNeoplasm MetastasisReceptor, Platelet-Derived Growth Factor alphaSignal TransductionTumor MicroenvironmentVirus Internalizationlysophosphatidic acidLysophospholipidsReceptor, Platelet-Derived Growth Factor alphaautotaxinchemokinescytokineslipid phosphate phosphataseslysophosphatidic acid

Identifiers

PMID34575976
PMCPMC8471290
OpenAlexW3199868184

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.