Evidence map›Paper›PMID 34576075›Full record

ArticleInternational journal of molecular sciences2021

C5a Activates a Pro-Inflammatory Gene Expression Profile in Human Gaucher iPSC-Derived Macrophages.

Jacquelyn C Serfecz, Afsoon Saadin, Clayton P Santiago, Yuji Zhang, Søren M Bentzen, Stefanie N Vogel, Ricardo A Feldman

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jacquelyn C SerfeczDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Afsoon SaadinDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Clayton P SantiagoThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Yuji ZhangDepartment of Epidemiology and Public Health, University of Maryland, Baltimore, MD 21201, USA.
Søren M BentzenDepartment of Epidemiology and Public Health, University of Maryland, Baltimore, MD 21201, USA.
Stefanie N VogelDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0001-8244-2555
Ricardo A FeldmanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USJohns Hopkins University · US

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Signaling Pathways in Innate ImmunityT32AI095190 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Stefanie N. Vogel · 2012 to 2026
$4.7M
Macrophage differentiation and disease outcome in influenza infectionR01AI123371 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI VOGEL, STEFANIE N. · 2017 to 2021
$2.7M
NCATS NIH HHS UL1 TR003098NIAID NIH HHS R01 AI123371NIAID NIH HHS T32 AI095190NIH HHS AI095190NIH HHS AI123371
6 · The paper itself

Abstract

Gaucher disease (GD) is an autosomal recessive disorder caused by bi-allelic

Indexed as

Gene Expression ProfilingGene Expression RegulationCell LineComplement C5aGaucher DiseaseHumansInduced Pluripotent Stem CellsInflammationMacrophagesOxidation-ReductionReceptor, Anaphylatoxin C5aRecombinant ProteinsTumor Necrosis Factor-alphaWnt Signaling PathwayC5AR1 protein, humanComplement C5aReceptor, Anaphylatoxin C5aRecombinant ProteinsTumor Necrosis Factor-alphaC5acomplementgaucher diseaseGBA1gene arraysinduced pluripotent stem cells (iPSC)inflammationmacrophagesTNF-alphaβ-glucocerebrosidase

Identifiers

PMID34576075
PMCPMC8466165
OpenAlexW3200454816

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.