ArticleInternational journal of molecular sciences2021
Increased Autotaxin Levels in Severe COVID-19, Correlating with IL-6 Levels, Endothelial Dysfunction Biomarkers, and Impaired Functions of Dendritic Cells.
Open access · goldAbstract read
In one paragraph
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Pooled it
- Plasma proteomics identifies early markers of endothelial and inflammatory activation associated with dengue disease severity in children.medRxiv : the preprint server for health sciences · 2026Article
- Biomarkers associated with the diagnosis and prognosis ofFrontiers in cellular and infection microbiology · 2025Review
- Identification of key gene expression associated with quality of life after recovery from COVID-19.Medical & biological engineering & computing · 2024Article
- Review
- Exploring common pathogenic association between Epstein Barr virus infection and long-COVID by integrating RNA-Seq and molecular dynamics simulations.Frontiers in immunology · 2024Article
- Predictive Value of Lysophosphatidylcholine for Determining the Disease Severity and Prognosis of Elderly Patients with Community-Acquired Pneumonia.Clinical interventions in aging · 2024Article
- The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer.International journal of molecular sciences · 2023Article
- COVID-19, Blood Lipid Changes, and Thrombosis.Biomedicines · 2023Review
- Role of autotaxin in systemic lupus erythematosus.Frontiers in medicine · 2023Review
- Elevated IFNA1 and suppressed IL12p40 associated with persistent hyperinflammation in COVID-19 pneumonia.Frontiers in immunology · 2023Article
- Decrease in serum levels of autotaxin in COVID-19 patients.Annals of medicine · 2022Article
- Identification and characterization of lysophosphatidylcholine 14:0 as a biomarker for drug-induced lung disease.Scientific reports · 2022Article
- Autotaxin Has a Negative Role in Systemic Inflammation.International journal of molecular sciences · 2022Article
- [Value of autotaxin in predicting refractoryZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Characterizing Kinetics and Avidity of SARS-CoV-2 Antibody Responses in COVID-19 Greek Patients.Viruses · 2022Article
- RAGE pathway activation and function in chronic kidney disease and COVID-19.Frontiers in medicine · 2022Review
- Commonalities Between ARDS, Pulmonary Fibrosis and COVID-19: The Potential of Autotaxin as a Therapeutic Target.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 1 country.
Ioanna NikitopoulouGP Livanos and M Simou Laboratories, 1st Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos General Hospital, 10676 Athens, Greece.
Dionysios FanidisInstitute of Bio-Innovation, Biomedical Sciences Research Center Alexander Fleming, 16672 Athens, Greece.ORCID 0000-0002-4053-2090
Konstantinos NtatsoulisInstitute of Bio-Innovation, Biomedical Sciences Research Center Alexander Fleming, 16672 Athens, Greece.ORCID 0000-0001-6452-301X
Panagiotis MoulosInstitute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, 16672 Athens, Greece.ORCID 0000-0002-4199-0333
George MpekoulisMolecular Virology Laboratory, Department of Diagnostics, Hellenic Pasteur Institute, 11521 Athens, Greece.
Maria EvangelidouDepartment of Diagnostics, Hellenic Pasteur Institute, 11521 Athens, Greece.
Alice G VassiliouGP Livanos and M Simou Laboratories, 1st Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos General Hospital, 10676 Athens, Greece.ORCID 0000-0003-4984-0476
Vasiliki DimakopoulouDepartment of Respiratory Medicine, University Hospital of Patras, 26504 Patras, Greece.
Edison Jahaj1st Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos General Hospital, 10676 Athens, Greece.ORCID 0000-0002-7306-713X
Stamatios Tsipilis1st Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos General Hospital, 10676 Athens, Greece.ORCID 0000-0003-2631-3809
Stylianos E Orfanos1st Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos General Hospital, 10676 Athens, Greece.
Ioanna Dimopoulou1st Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos General Hospital, 10676 Athens, Greece.
Emmanouil AngelakisDepartment of Diagnostics, Hellenic Pasteur Institute, 11521 Athens, Greece.
Karolina AkinosoglouDepartment of Respiratory Medicine, University Hospital of Patras, 26504 Patras, Greece.
Niki VassilakiMolecular Virology Laboratory, Department of Diagnostics, Hellenic Pasteur Institute, 11521 Athens, Greece.
Argyrios TzouvelekisDepartment of Respiratory Medicine, University Hospital of Patras, 26504 Patras, Greece.
Anastasia KotanidouGP Livanos and M Simou Laboratories, 1st Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos General Hospital, 10676 Athens, Greece.ORCID 0000-0002-2508-500X
Vassilis AidinisInstitute of Bio-Innovation, Biomedical Sciences Research Center Alexander Fleming, 16672 Athens, Greece.ORCID 0000-0001-9531-7729
National and Kapodistrian University of Athens · GRAlexander Fleming Biomedical Sciences Research Center · GRPasteur Hellenic Institute · GRGeneral University Hospital of Patras · GR
Funding
General secreteriat of research and technology T1EDK-0049
Abstract
Autotaxin (ATX;
Indexed as
AdultAgedAged, 80 and overBiomarkersCohort StudiesCOVID-19Datasets as TopicDendritic CellsDexamethasoneEndothelium, VascularFemaleHumansInterleukin-6Lysophospholipase DMaleMiddle AgedBiomarkersDexamethasoneIL6 protein, humanInterleukin-6Lysophospholipase DPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesARDSautotaxin (ATXCOVID-19cytokine stormdendritic cells (DCs)ENPP2)lysophosphatidic acid (LPA)pulmonary fibrosisvascular dysfunction
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.