Evidence map›Paper›PMID 34576210›Full record

ArticleInternational journal of molecular sciences2021

Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations.

Carina Höring, Marcus Conrad, Christian A Söldner, Jinan Wang, Heinrich Sticht, Andrea Strasser, Yinglong Miao

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Molecular Biology of Histamine System, Volume 1.International journal of molecular sciences · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carina HöringInstitute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.ORCID 0000-0002-6536-277X
Marcus ConradBioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054 Erlangen, Germany.
Christian A SöldnerBioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054 Erlangen, Germany.ORCID 0000-0002-5839-1468
Jinan WangDepartment of Computational Biology and Molecular Biosciences, University of Kansas, Lawrence, KS 66047, USA.ORCID 0000-0003-0162-212X
Heinrich StichtBioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054 Erlangen, Germany.ORCID 0000-0001-5644-045X
Andrea StrasserInstitute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.
Yinglong MiaoDepartment of Computational Biology and Molecular Biosciences, University of Kansas, Lawrence, KS 66047, USA.

Funding

Deutsche Forschungsgemeinschaft 222125149
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) are targets of extracellular stimuli and hence occupy a key position in drug discovery. By specific and not yet fully elucidated coupling profiles with α subunits of distinct G protein families, they regulate cellular responses. The histamine H

Indexed as

LigandsMolecular Dynamics SimulationComputer SimulationCryoelectron MicroscopyDrug Delivery SystemsGTP-Binding ProteinsHEK293 CellsHistamineHumansLuciferasesNormal DistributionProtein BindingProtein ConformationProtein EngineeringProtein Structure, SecondaryReceptors, HistamineGTP-Binding ProteinsHistamineLigandsLuciferasesReceptors, HistamineReceptors, Histamine H2Receptors, Histamine H4engineered G proteinsGaussian accelerated molecular dynamics (GaMD)GPCR–G protein coupling profileshistamine H2 receptorhistamine H4 receptorhistamine signalingsplit-luciferase complementation assay

Identifiers

PMID34576210
PMCPMC8467750

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.