Evidence mapPaperPMID 34576247Full record

ReviewInternational journal of molecular sciences2021

Chronic Kidney Disease: Strategies to Retard Progression.

Ming-Tso Yan, Chia-Ter Chao, Shih-Hua Lin

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 2 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. [Rehmanniae radix preparata alleviates chronic kidney disease in mice through a multi-target mechanism].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ming-Tso YanDepartment of Medicine, Division of Nephrology, Cathay General Hospital, School of Medicine, Fu-Jen Catholic University, Taipei 106, Taiwan.
Chia-Ter ChaoDepartment of Internal Medicine, Nephrology Division, National Taiwan University Hospital, Taipei 104, Taiwan.ORCID 0000-0003-2892-7986
Shih-Hua LinNational Defense Medical Center, Graduate Institute of Medical Sciences, Taipei 114, Taiwan.ORCID 0000-0001-6152-4885

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD), defined as the presence of irreversible structural or functional kidney damages, increases the risk of poor outcomes due to its association with multiple complications, including altered mineral metabolism, anemia, metabolic acidosis, and increased cardiovascular events. The mainstay of treatments for CKD lies in the prevention of the development and progression of CKD as well as its complications. Due to the heterogeneous origins and the uncertainty in the pathogenesis of CKD, efficacious therapies for CKD remain challenging. In this review, we focus on the following four themes: first, a summary of the known factors that contribute to CKD development and progression, with an emphasis on avoiding acute kidney injury (AKI); second, an etiology-based treatment strategy for retarding CKD, including the approaches for the common and under-recognized ones; and third, the recommended approaches for ameliorating CKD complications, and the final section discusses the novel agents for counteracting CKD progression.

Indexed as

AcidosisAcute Kidney InjuryAnemiaCulture Media, ConditionedDiabetes ComplicationsDiabetes MellitusDisease ProgressionEpithelial-Mesenchymal TransitionGlomerular Filtration RateHumansHyperkalemiaHypertensionKidney Failure, ChronicMesenchymal Stem CellsNephrolithiasisRenal Insufficiency, ChronicCulture Media, Conditionedacute kidney injurychronic kidney diseaserenal progressiontherapy for renal failure

Identifiers

PMID34576247
PMCPMC8470895

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.