Evidence map›Paper›PMID 34576336›Full record

ArticleInternational journal of molecular sciences2021

Silica Nanoparticles Inhibit Responses to ATP in Human Airway Epithelial 16HBE Cells.

Alina Milici, Alicia Sanchez, Karel Talavera

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alina MiliciLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, VIB Center for Brain & Disease Research, Herestraat 49, 3000 Leuven, Belgium.ORCID 0000-0002-6706-7766
Alicia SanchezLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, VIB Center for Brain & Disease Research, Herestraat 49, 3000 Leuven, Belgium.
Karel TalaveraLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, VIB Center for Brain & Disease Research, Herestraat 49, 3000 Leuven, Belgium.
VIB-KU Leuven Center for Brain & Disease Research · BE

Funding

European Commission KA 103-061892Fonds Wetenschappelijk Onderzoek G076714Onderzoeksraad, KU Leuven GOA/14/011
6 · The paper itself

Abstract

Because of their low cost and easy production, silica nanoparticles (SiNPs) are widely used in multiple manufacturing applications as anti-caking, densifying and hydrophobic agents. However, this has increased the exposure levels of the general population and has raised concerns about the toxicity of this nanomaterial. SiNPs affect the function of the airway epithelium, but the biochemical pathways targeted by these particles remain largely unknown. Here we investigated the effects of SiNPs on the responses of 16HBE14o- cultured human bronchial epithelial (16HBE) cells to the damage-associated molecular pattern ATP, using fluorometric measurements of intracellular Ca

Indexed as

Adenosine TriphosphateAnimalsEpithelial CellsHumansNanoparticlesOxidative StressSilicon DioxideAdenosine TriphosphateSilicon DioxideairwayATPepithelial cellintracellular Ca2+nanoparticlespurinergic receptorsilica

Identifiers

PMID34576336
PMCPMC8467126
OpenAlexW3200598610

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.