Evidence map›Paper›PMID 34576949›Full record

ArticleMolecules (Basel, Switzerland)2021

The Effect of Betulin Diphosphate in Wound Dressings of Bacterial Cellulose-ZnO NPs on Platelet Aggregation and the Activity of Oxidoreductases Regulated by NAD(P)+/NAD(P)H-Balance in Burns on Rats.

Nina Melnikova, Darina Malygina, Alyona Balakireva, Peter Peretyagin, Vadim Revin, Anna Devyataeva, Kseniya Malafeeva, Viktor Revin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Advances in nucleic acid delivery strategies for diabetic wound therapy.Journal of clinical & translational endocrinology · 2024
    Review
  2. Article
  3. Secondary Metabolites Found among the SpeciesMolecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nina MelnikovaFaculty of Chemistry, Lobachevsky University, 23/5 Gagarin Av., 603950 Nizhny Novgorod, Russia.ORCID 0000-0003-1335-1048
Darina MalyginaDepartment of Pharmaceutical Chemistry, Privolzhsky Research Medical University, 10/1 Minin Sq., 603950 Nizhny Novgorod, Russia.
Alyona BalakirevaCentral Research Laboratory, Privolzhsky Research Medical University, 10/1 Minin Sq., 603950 Nizhny Novgorod, Russia.
Peter PeretyaginCentral Research Laboratory, Privolzhsky Research Medical University, 10/1 Minin Sq., 603950 Nizhny Novgorod, Russia.
Vadim RevinDepartment of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia.
Anna DevyataevaDepartment of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia.
Kseniya MalafeevaDepartment of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia.
Viktor RevinDepartment of Biotechnology, Bioengineering and Biochemistry, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia.ORCID 0000-0001-6542-2667
National Research Mordovia State University · RUPrivolzhsky Research Medical University · RUN. I. Lobachevsky State University of Nizhny Novgorod · RU

Funding

Russian Foundation for Basic Research FZRS-2020-0003
6 · The paper itself

Abstract

The inhibition of platelet aggregation, and the activity of oxidoreductases and microhemocirculation in a burn wound on the treatment of burns with wound dressings based on bacterial nanocellulose (BC)-zinc oxide nanoparticles (ZnO NPs)-betulin diphosphate (BDP) were studied. The control of the treatment by BC-ZnO NPs-BDP on burned rats by the noninvasive DLF method showed an increase in perfusion and the respiratory component in wavelet spectra, characterizing an improvement in oxygen saturation in the wound. The study on the volunteers' blood found the inhibition of ADP-induced platelet aggregation by 30-90%. Disaggregation depends on the dose under the action of the ionized form of BDP and ZnO NPs-BDP in a phosphate buffer; it was reversible and had two waves. It was shown on rats that the specific activity of LDH

Indexed as

BandagesAcetobacteraceaeAnimalsBetulinic AcidBurnsCelluloseDiphosphatesGlucosephosphate DehydrogenaseGlutathione ReductaseHumansLaser-Doppler FlowmetryMaleMetal NanoparticlesNADPPlatelet AggregationRatsbetulinBetulinic AcidCelluloseDiphosphatesGlucosephosphate DehydrogenaseGlutathione ReductaseNADPTriterpenesanti-aggregationbacterial cellulosebetulin diphosphateoxidoreductase activitywound dressingsZnO NPs

Identifiers

PMID34576949
PMCPMC8469126
OpenAlexW3198335674

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.