Evidence map›Paper›PMID 34577088›Full record

ArticleMolecules (Basel, Switzerland)2021

GPCR Pharmacological Profiling of Aaptamine from the Philippine Sponge

Harmie Luyao, Hendrik Luesch, Mylene Uy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Aaptamine Inhibits Lipid Accumulation andJournal of experimental pharmacology · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Harmie LuyaoDepartment of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City 9200, Philippines.
Hendrik LueschDepartment of Medicinal Chemistry and Center for Natural Products, Drug Discovery, and Development (CNPD3), University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-4091-7492
Mylene UyDepartment of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City 9200, Philippines.
Mindanao State University – Iligan Institute of Technology · PHUniversity of Florida · US

Funding

Novel Targeted Anticancer Agents from Marine CyanobacteriaR01CA172310 · NCI · UNIVERSITY OF FLORIDA · PI HENDRIK LUESCH · 2013 to 2026
$5.8M
Department of Science and Technology, Philippines DOST-SEI, DOST-PCHRDNCI NIH HHS R01 CA172310
6 · The paper itself

Abstract

We report the first isolation of the alkaloid aaptamine from the Philippine marine sponge

Indexed as

Adrenergic AntagonistsAlkaloidsAllosteric RegulationAnimalsCell Line, TumorCell SurvivalDopamine AntagonistsHumansNaphthyridinesNoncommunicable DiseasesPhilippinesPoriferaReceptors, AdrenergicReceptors, ChemokineReceptors, DopamineReceptors, G-Protein-CoupledaaptamineAdrenergic AntagonistsAlkaloidsDopamine AntagonistsNaphthyridinesReceptors, AdrenergicReceptors, ChemokineReceptors, DopamineReceptors, G-Protein-CoupledaaptamineADRA2CADRB2CXCR7DRD4GPCRsNCDs

Identifiers

PMID34577088
PMCPMC8466755
OpenAlexW3198964060

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.