Evidence map›Paper›PMID 34577136›Full record

ArticleMolecules (Basel, Switzerland)2021

Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as a PRC2 Modulator.

Sang Ah Yi, Ki Hong Nam, Min Gyu Lee, Hwamok Oh, Jae Sung Noh, Jae Kyun Jeong, Sangwoo Kwak, Ye Ji Jeon, So Hee Kwon, Jaecheol Lee and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sang Ah YiSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0002-7048-0252
Ki Hong NamSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Min Gyu LeeSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Hwamok OhSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Jae Sung NohSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Jae Kyun JeongSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Sangwoo KwakSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Ye Ji JeonSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
So Hee KwonCollege of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, International Campus, Yonsei University, Incheon 21983, Korea.ORCID 0000-0002-3753-4415
Jaecheol LeeSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Jeung-Whan HanSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Sungkyunkwan University · KRYonsei University · KR

Funding

National Research Foundation of Korea 2017R1A2B3002186National Research Foundation of Korea 2017R1A6A3A04001986National Research Foundation of Korea 2019R1A5A2027340National Research Foundation of Korea 2019R1C1C1010675
6 · The paper itself

Abstract

Extensive epigenetic remodeling occurs during the cell fate determination of stem cells. Previously, we discovered that eudesmin regulates lineage commitment of mesenchymal stem cells through the inhibition of signaling molecules. However, the epigenetic modulations upon eudesmin treatment in genomewide level have not been analyzed. Here, we present a transcriptome profiling data showing the enrichment in PRC2 target genes by eudesmin treatment. Furthermore, gene ontology analysis showed that PRC2 target genes downregulated by eudesmin are closely related to Wnt signaling and pluripotency. We selected

Indexed as

Gene Expression ProfilingPolycomb Repressive Complex 2Wnt Signaling PathwayBiological ProductsEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticGene Expression RegulationHumansIntercellular Signaling Peptides and ProteinsMesenchymal Stem CellsTranscriptomeBiological ProductsDKK1 protein, humanEnhancer of Zeste Homolog 2 ProteinIntercellular Signaling Peptides and ProteinsPolycomb Repressive Complex 2eudesminpluripotencypolycomb repressive complex 2transcriptomewnt

Identifiers

PMID34577136
PMCPMC8465685
OpenAlexW3199367788

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.