Trial reportNutrients2021
L-Citrulline Supplementation and Exercise in the Management of Sarcopenia.
Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.BMC women's health · 2026Pooled it
- Effects of Citrulline or Watermelon Supplementation on Body Composition: A Systematic Review and Dose-Response Meta-Analysis.Nutrients · 2025Pooled it
- The Effects of Combined Exercise with Citrulline Supplementation on Body Composition and Lower Limb Function of Overweight Older Adults: A Systematic Review and Meta-Analysis.Journal of sports science & medicine · 2023Pooled it
- Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes.Nutrients · 2025Trial
- Combined Vs. Single Supplementation of L-Citrulline and Sodium Bicarbonate During Sprint Interval Training in Basketball Players: Effects on Physical Performance and Hormonal Adaptations.Journal of sports science & medicine · 2025Trial
- Effects of oral oligopeptide preparation and exercise intervention in older people with sarcopenia: a randomized controlled trial.BMC geriatrics · 2024Trial
- Trial
- Nitric-Oxide-Inducing Factors on Vitamin D Changes in Older People Susceptible to Suffer from Sarcopenia.International journal of environmental research and public health · 2022Trial
- Potential role of L-citrulline in regulating exercise performance and muscle protein metabolism.NPJ science of food · 2026Review
- Network pharmacology analysis and in vitro verification of the anti-sarcopenia effects of formononetin.Bioresources and bioprocessing · 2025Article
- The effects of L-citrulline supplementation on cerebrovascular function during sprint interval training in taekwondo athletes.Journal of exercise science and fitness · 2025Article
- Sarcopenia prevention in older adults: Effectiveness and limitations of non-pharmacological interventions.Osteoporosis and sarcopenia · 2025Review
- Impact of GLP- 1 Receptor Agonist Therapy in Patients High Risk for Sarcopenia.Current nutrition reports · 2025Review
- Targeting muscle-vasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention.Frontiers in nutrition · 2025Review
- Effect of five non-invasive treatments on body composition, physical function and quality of life in elderly sarcopenia: a network meta-analysis of 22 randomized controlled trials.Frontiers in physiology · 2025Review
- Type 2 diabetes-related sarcopenia: role of nitric oxide.Nutrition & metabolism · 2024Review
- Inverse association between uric acid levels and muscle quality index in adults: a cross-sectional analysis of NHANES 2011-2014.BMC public health · 2024Article
- Review
- Article
- Dysregulation of acyl carnitines, pentose phosphate pathway and arginine and ornithine metabolism are associated with decline in intrinsic capacity in Chinese older adults.Aging clinical and experimental research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia is a process associated to aging. Persistent inflammation and oxidative stress in muscle favour muscle wasting and decreased ability to perform physical activity. Controlled exercise can optimize blood flux and moderate the production of reactive oxygen species. Therefore, supplements that can work as a vasodilators and control oxidative stress, might be beneficial for active elders. In this context, we have tested citrulline supplementation in a group of 44 participants aged from 60-73 years that followed a physical activity program adapted to their age and capacities. Volunteers were divided in two groups: placebo (
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.