Evidence map›Paper›PMID 34579571›Full record

ArticlemBio2021

Heterogeneous Flagellar Expression in Single Salmonella Cells Promotes Diversity in Antibiotic Tolerance.

Zhihui Lyu, Angela Yang, Patricia Villanueva, Abhyudai Singh, Jiqiang Ling

Abstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. A Novel Indigoidine-like NRPS Gene fromAntioxidants (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Induced tolerance to UV stress drives survival heterogeneity in isogenicbioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Infection and immunity · 2024
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Motility-activating mutations upstream ofMicrobiology spectrum · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhihui LyuDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.
Angela YangDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.
Patricia VillanuevaDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.
Abhyudai SinghDepartment of Electrical and Computer Engineering and Biomedical Engineering, University of Delaware, Newark, Delaware, USA.
Jiqiang LingDepartment of Cell Biology and Molecular Genetics, The University of Maryland, College Park, Maryland, USA.ORCID 0000-0003-4466-8304

Funding

Regulation and Physiological Roles of Translational FidelityR35GM136213 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI LING, JIQIANG · 2020 to 2024
$2.0M
Physiological impact of reduced fidelity in protein synthesisR01GM115431 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI LING, JIQIANG · 2015 to 2019
$1.5M
Consequences and Control of Randomness in Timing of Intracellular EventsR01GM124446 · NIGMS · UNIVERSITY OF DELAWARE · PI SINGH, ABHYUDAI · 2017 to 2020
$914k
NIGMS NIH HHS R01 GM115431NIGMS NIH HHS R01 GM124446NIGMS NIH HHS R35 GM136213
6 · The paper itself

Abstract

Phenotypic heterogeneity among single cells in a genetically identical population leads to diverse environmental adaptation. The human and animal pathogen Salmonella enterica serovar Typhimurium exhibits heterogeneous expression of virulence genes, including flagellar and Salmonella pathogenicity island (SPI) genes. Little is known about how the differential expression of flagellar genes among single cells affects bacterial adaptation to stresses. Here, we have developed a triple-fluorescence reporter to simultaneously monitor the expression of flagellar and SPI-1 pathways. We show that the two pathways cross talk at the single-cell level. Intriguingly, cells expressing flagella (

Indexed as

Drug Resistance, BacterialAnti-Bacterial AgentsBacterial ProteinsFlagellaFlagellinGene Expression Regulation, BacterialGenomic IslandsSalmonella typhimuriumAnti-Bacterial AgentsBacterial ProteinsFlagellinantibiotic toleranceflagellapathogenesisSalmonellasingle cell

Identifiers

PMID34579571
PMCPMC8546535

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.