ArticleHuman reproduction (Oxford, England)2021
Genetic incompatibility of the reproductive partners: an evolutionary perspective on infertility.
Article in Human reproduction (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- ESHRE's key research priorities in infertility: maximizing impact on science, people and society†.Human reproduction (Oxford, England) · 2025Article
- Female-mediated selective sperm activation may remodel major histocompatibility complex-based mate choice decisions in humans.Heredity · 2025Article
- Changing sperm donors-a shortcut to pregnancy or just a myth?Journal of assisted reproduction and genetics · 2025Article
- Solutions to the fertility equation in beef embryo recipients.Animal reproduction · 2024Review
- Interplay between male quality and male-female compatibility across episodes of sexual selection.Science advances · 2023Article
- Reprotoxic Effect of Tris(2,3-Dibromopropyl) Isocyanurate (TBC) on Spermatogenic Cells In Vitro.Molecules (Basel, Switzerland) · 2023Article
- What Does Intracytoplasmic Sperm Injection Change in Embryonic Development? The Spermatozoon Contribution.Journal of clinical medicine · 2023Review
- Cryptic female choice within individual males - A neglected component of the postmating sexual selection?Journal of evolutionary biology · 2022Review
- Parental fecundability and neurodevelopmental delays and difficulties in offspring.International journal of epidemiology · 2022Article
- Opportunities and Limits of Conventional IVF versus ICSI: It Is Time to Come off the Fence.Journal of clinical medicine · 2022Review
- Sperm Physiological Response to Female Serum-Potential New Insights into the Reproductive Incompatibility Diagnostics.International journal of molecular sciences · 2022Article
- Female-induced selective modification of sperm protein SUMOylation-potential mechanistic insights into the non-random fertilization in humans.Journal of evolutionary biology · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In natural fertilisation, the female reproductive tract allows only a strictly selected sperm subpopulation to proceed in the vicinity of an unfertilised oocyte. Female-mediated sperm selection (also known as cryptic female choice (CFC)) is far from a random process, which frequently biases paternity towards particular males over others. Earlier studies have shown that CFC is a ubiquitous phenomenon in the animal kingdom and often promotes assortative fertilisation between genetically compatible mates. Here, I demonstrate that CFC for genetic compatibility likely also occurs in humans and is mediated by a complex network of interacting male and female genes. I also show that the relative contribution of genetic compatibility (i.e. the male-female interaction effect) to reproductive success is generally high and frequently outweighs the effects of individual males and females. Together, these facts indicate that, along with male- and female-dependent pathological factors, reproductive failure can also result from gamete-level incompatibility of the reproductive partners. Therefore, I argue that a deeper understanding of these evolutionary mechanisms of sperm selection can pave the way towards a more inclusive view of infertility and open novel possibilities for the development of more personalised infertility diagnostics and treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.