Evidence map›Paper›PMID 34583607›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Anti-influenza A virus activity and structure-activity relationship of a series of nitrobenzoxadiazole derivatives.

Francesco Fiorentino, Marta De Angelis, Martina Menna, Annarita Rovere, Anna Maria Caccuri, Francesca D'Acunzo, Anna Teresa Palamara, Lucia Nencioni, Dante Rotili, Antonello Mai

Abstract read
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In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francesco FiorentinoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-3550-1860
Marta De AngelisDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-1916-6508
Martina MennaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.
Annarita RovereDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.
Anna Maria CaccuriDepartment of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0002-3756-4163
Francesca D'AcunzoCNR, Istituto di Metodologie Chimiche, Sezione Meccanismi di Reazione, Sapienza University of Rome, Rome, Italy.
Anna Teresa PalamaraDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-8330-4381
Lucia NencioniDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-4427-4823
Dante RotiliDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-8428-8763
Antonello MaiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-9176-2382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza viruses represent a major threat to human health and are responsible for seasonal epidemics, along with pandemics. Currently, few therapeutic options are available, with most drugs being at risk of the insurgence of resistant strains. Hence, novel approaches targeting less explored pathways are urgently needed. In this work, we assayed a library of nitrobenzoxadiazole derivatives against the influenza virus A/Puerto Rico/8/34 H1N1 (PR8) strain. We identified three promising 4-thioether substituted nitrobenzoxadiazoles (

Indexed as

4-Chloro-7-nitrobenzofurazanAnimalsAntiviral AgentsCells, CulturedCell SurvivalDogsDose-Response Relationship, DrugHumansInfluenza A Virus, H1N1 SubtypeMicrobial Sensitivity TestsMolecular StructureStructure-Activity Relationship4-Chloro-7-nitrobenzofurazanAntiviral AgentsantiviralsInfluenza A virusnitrobenzoxadiazolesRNA polymerase inhibitors

Identifiers

PMID34583607
PMCPMC8480593

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.