Evidence map›Paper›PMID 34585667›Full record

ArticleeLife2021

Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in

João L Silva-Filho, João Ck Dos-Santos, Carla Judice, Dario Beraldi, Kannan Venugopal, Diogenes Lima, Helder I Nakaya, Erich V De Paula, Stefanie Cp Lopes, Marcus Vg Lacerda and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Comparable severity ofNew microbes and new infections · 2026
    Article
  4. Article
  5. Serum Proteomics Reveals Systemic Responses inPathogens (Basel, Switzerland) · 2025
    Article
  6. Malaria.The New England journal of medicine · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Sterile protection againstLife science alliance · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Ectopic Expression ofMicroorganisms · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

João L Silva-Filho *Laboratory of Tropical Diseases - Prof. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.ORCID 0000-0003-4762-2205
João Ck Dos-Santos *Laboratory of Tropical Diseases - Prof. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.ORCID 0000-0001-5916-9845
Carla JudiceLaboratory of Tropical Diseases - Prof. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.ORCID 0000-0003-1839-053X
Dario BeraldiWellcome Centre for Integrative Parasitology, Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom.
Kannan VenugopalWellcome Centre for Integrative Parasitology, Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom.
Diogenes LimaSchool of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Helder I NakayaSchool of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0000-0001-5297-9108
Erich V De PaulaDepartment of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, Brazil.
Stefanie Cp LopesDepartment of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, Brazil.
Marcus Vg LacerdaInstitute Leônidas & Maria Deane, Fiocruz, Manaus, Brazil.
Matthias MartiWellcome Centre for Integrative Parasitology, Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0003-1040-9566
Fabio Tm CostaLaboratory of Tropical Diseases - Prof. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.ORCID 0000-0001-9969-7300
Universidade Estadual de Campinas (UNICAMP) · BRWellcome Centre for Molecular Parasitology · GBUniversidade de São Paulo · BRFundação de Medicina Tropical · BR

Funding

Wellcome Trust 104111
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultBiomassFemaleHumansMalaria, VivaxMaleMiddle AgedParasitemiaPlasmodium vivaxYoung Adultendothelial activationhaematopoiesishumaninfectious diseasemalaria parasitemicrobiologyPlasmodium vivaxtissue infectiontotal biomass

Identifiers

PMID34585667
PMCPMC8536259
OpenAlexW3203057926

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.