Evidence map›Paper›PMID 34586848›Full record

ArticleScience advances2021

Shinichi Fukuda, Siddharth Narendran, Akhil Varshney, Yosuke Nagasaka, Shao-Bin Wang, Kameshwari Ambati, Ivana Apicella, Felipe Pereira, Benjamin J Fowler, Tetsuhiro Yasuma and 29 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
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  5. Article
  6. Article
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  8. Association of nucleoside reverse transcriptase inhibitor use with reduced risk of Alzheimer's disease risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Shinichi FukudaCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Siddharth NarendranCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0002-9220-8049
Akhil VarshneyCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Yosuke NagasakaCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Shao-Bin WangCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0002-6699-9406
Kameshwari AmbatiCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Ivana ApicellaCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Felipe PereiraCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0001-8884-2816
Benjamin J FowlerDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY, USA.
Tetsuhiro YasumaDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shuichiro HiraharaCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Reo YasumaCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0001-6205-1151
Peirong HuangCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0003-2793-1473
Praveen YerramothuCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Ryan D MakinCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0002-8804-4125
Mo WangDoheny Eye Institute, Los Angeles, CA, USA.
Kirstie L BakerDoheny Eye Institute, Los Angeles, CA, USA.ORCID 0000-0003-3953-4352
Kenneth M MarionDoheny Eye Institute, Los Angeles, CA, USA.ORCID 0000-0003-1275-5729
Xiwen HuangDoheny Eye Institute, Los Angeles, CA, USA.
Elmira BaghdasaryanDoheny Eye Institute, Los Angeles, CA, USA.
Meenakshi AmbatiCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Vidya L AmbatiCenter for Digital Image Evaluation, Charlottesville, VA, USA.
Daipayan BanerjeeCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Vera L BonilhaCole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-6166-5124
Genrich V TolstonogDepartment of Otolaryngology-Head and Neck Surgery, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-5560-4157
Ulrike HeldDepartment of Medical Biotechnology, Paul-Ehrlich-Institute, Langen, Germany.
Yuichiro OguraDepartment of Ophthalmology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Hiroko TerasakiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0003-2879-4220
Tetsuro OshikaDepartment of Ophthalmology, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.ORCID 0000-0002-9071-7018
Deepak BhattaraiDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA.
Kyung Bo KimDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA.ORCID 0000-0003-4744-2466
Sanford H FeldmanCenter for Comparative Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
J Ignacio AguirreDepartment of Physiological Sciences, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-8100-5839
David R HintonDepartments of Pathology and Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Nagaraj KerurCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.
Srinivas R SaddaDoheny Eye Institute, Los Angeles, CA, USA.
Gerald G SchumannDepartment of Medical Biotechnology, Paul-Ehrlich-Institute, Langen, Germany.
Bradley D GelfandCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0003-4619-9409
Jayakrishna AmbatiCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0003-1622-6365

Funding

RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI Brian D Perkins · 2016 to 2026
$7.7M
EXPERIMENTAL APPROACH TO MACULOPATHYR01EY001545 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HINTON, DAVID R. · 1985 to 2016
$6.0M
Form and function of our Janus faced genomeDP1GM114862 · NIGMS · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2014 to 2018
$4.0M
KENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR033173 · NCRR · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2011 to 2011
$3.5M
Functional studies of DICER1 and Alu RNA in geographic atrophyR01EY022238 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2012 to 2016
$3.3M
Visual system and cognitive biology in normal animals versus in an animal model of Alzheimer's disease with or without diabetes treated with solo or dual inflammasome inhibitorsR01EY031039 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA, GELFAND, BRADLEY DAVID · 2020 to 2024
$3.2M
Non-canonical cGAS signaling in DNA damage responseR01AI148741 · NIAID · UNIVERSITY OF VIRGINIA · PI KERUR, NAGARAJ · 2020 to 2025
$3.1M
Non-canonical inflammasome in activation in RPE degenerationR01EY029799 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2019 to 2022
$2.7M
Inflammasome Activation in Geographic AtrophyR01EY024068 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2014 to 2017
$2.6M
Clinical Scholars In Cardiovascular ScienceT32HL091812 · NHLBI · UNIVERSITY OF KENTUCKY · PI SMYTH, SUSAN S. · 2008 to 2018
$2.3M
Antigen-independent suppression of ocular angiogenesis via the Fc receptorR01EY028027 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA, GELFAND, BRADLEY DAVID · 2018 to 2022
$2.2M
DICER1 deficiency in aberrant chorioretinal neovascularization - Administrative Supplement OKT RequestR01EY032512 · NEI · UNIVERSITY OF VIRGINIA · PI GELFAND, BRADLEY DAVID · 2021 to 2024
$2.1M
NCRR NIH HHS UL1 RR033173NEI NIH HHS K99 EY024336NEI NIH HHS P30 EY025585NEI NIH HHS R00 EY024336NEI NIH HHS R01 EY001545NEI NIH HHS R01 EY022238NEI NIH HHS R01 EY024068NEI NIH HHS R01 EY027750NEI NIH HHS R01 EY028027NEI NIH HHS R01 EY029799NEI NIH HHS R01 EY031039NEI NIH HHS R01 EY032512NEI NIH HHS R21 EY030651NHLBI NIH HHS T32 HL091812NIAID NIH HHS R01 AI148741NIGMS NIH HHS DP1 GM114862
6 · The paper itself

Abstract

Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of

Identifiers

PMID34586848
PMCPMC8480932

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.