Evidence map›Paper›PMID 34590174›Full record

ArticleDiabetologia2021

The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Richard I G Holt, J Hans DeVries, Amy Hess-Fischl, Irl B Hirsch, M Sue Kirkman, Tomasz Klupa, Barbara Ludwig, Kirsten Nørgaard, Jeremy Pettus, Eric Renard and 4 more

Erratum issued 2 registry-linked trialsOpen access · bronzeAbstract readConsensus Statement
In one paragraph

Article in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 186 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 7 pooled it
33.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06985095 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effectiveness of a Structured Nutrition Educational Program on Glycemic Control, Quality of Life, and Cardiovascular Risk in Patients With Uncontrolled Diabetes Using Multiple Daily Insulin Injections

TypeinterventionalSponsorCho Ray HospitalRan2025 to 2026Enrolled115ConditionsDiabetes MellitusArmsNutrition educational program
NCT07503028 early_phase1enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

An Exploratory Clinical Study Evaluating Allogeneic iPSC-derived Pancreatic Islet Cells (CRG-002) for the Treatment of Diabetic Patients With Hypoglycemia Unawareness or Severe Hypoglycemic Events

TypeinterventionalSponsorCelregen TherapeuticsRan2025 to 2028Enrolled10ConditionsT1DM - Type 1 Diabetes Mellitus, Pancreatogenic Diabetes MellitusArmsCRG002
3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 7 syntheses or guidelines pooled it, 348 citations in OpenAlex.

  1. [Diabetes technology (Update 2026)].Wiener klinische Wochenschrift · 2026
    Guideline
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  6. Real-World Evidence of Automated Insulin Delivery System Use.Diabetes technology & therapeutics · 2024
    Pooled it
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  20. Insulin Injection Behaviors and Association with Glycemic Outcomes in Patients with Diabetes: A Real-World Survey in Spain.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Article

126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 13 institutions in 7 countries.

Richard I G HoltHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK. righ@soton.ac.uk.
J Hans DeVriesAmsterdam UMC, Internal Medicine, University of Amsterdam, Amsterdam, the Netherlands.
Amy Hess-FischlKovler Diabetes Center, University of Chicago, Chicago, IL, USA.
Irl B HirschUW Medicine Diabetes Institute, Seattle, WA, USA.
M Sue KirkmanUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.
Tomasz KlupaDepartment of Metabolic Diseases, Center for Advanced Technologies in Diabetes, Jagiellonian University Medical College, Kraków, Poland.
Barbara LudwigUniversity Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Kirsten NørgaardSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Jeremy PettusUniversity of California, San Diego, CA, USA.
Eric RenardMontpellier University Hospital, Montpellier, France.
Jay S SkylerUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Frank J SnoekAmsterdam UMC, Medical Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Ruth S WeinstockSUNY Upstate Medical University, Syracuse, NY, USA.
Anne L PetersKeck School of Medicine of USC, Los Angeles, CA, USA.
Amsterdam University Medical Centers · NLIT University of Copenhagen · DKJagiellonian University · PLKeck Hospital of USC · USSeattle University · USSUNY Upstate Medical University · USUniversité de Montpellier · FRUniversity Hospital Carl Gustav Carus · DEUniversity of California, San Diego · USUniversity of Chicago · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · USUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a writing group to develop a consensus statement on the management of type 1 diabetes in adults. The writing group has considered the rapid development of new treatments and technologies and addressed the following topics: diagnosis, aims of management, schedule of care, diabetes self-management education and support, glucose monitoring, insulin therapy, hypoglycaemia, behavioural considerations, psychosocial care, diabetic ketoacidosis, pancreas and islet transplantation, adjunctive therapies, special populations, inpatient management and future perspectives. Although we discuss the schedule for follow-up examinations and testing, we have not included the evaluation and treatment of the chronic microvascular and macrovascular complications of diabetes as these are well-reviewed and discussed elsewhere. The writing group was aware of both national and international guidance on type 1 diabetes and did not seek to replicate this but rather aimed to highlight the major areas that healthcare professionals should consider when managing adults with type 1 diabetes. Though evidence-based where possible, the recommendations in the report represent the consensus opinion of the authors. Graphical abstract.

Indexed as

Diabetes Mellitus, Type 1AdultBlood GlucoseBlood Glucose Self-MonitoringConsensusHumansHypoglycemic AgentsInsulinBlood GlucoseHypoglycemic AgentsInsulinAdjunctive therapyDiabetic ketoacidosisDiagnosisExerciseGlucose monitoringHypoglycaemiaInsulinNutritionPsychosocial careSchedule of careTransplantationType 1 diabetes

Identifiers

PMID34590174
PMCPMC8481000
OpenAlexW3203693224

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.