Evidence map›Paper›PMID 34593620›Full record

ArticleJournal for immunotherapy of cancer2021

CD8

Sung-Woo Lee, He Yun Choi, Gil-Woo Lee, Therasa Kim, Hyun-Ju Cho, In-Jae Oh, Sang Yun Song, Deok Hwan Yang, Jae-Ho Cho

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
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  6. Progressive accumulation of circulating CD27Experimental & molecular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sung-Woo Lee *Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongsangbukdo, Republic of Korea.
He Yun Choi *Department of Internal Medicine, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea.
Gil-Woo LeeDivision of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongsangbukdo, Republic of Korea.
Therasa KimDepartment of Internal Medicine, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea.
Hyun-Ju ChoDepartment of Internal Medicine, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea.
In-Jae OhDepartment of Internal Medicine, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea.
Sang Yun SongDepartment of Thoracic and Cardiovascular Surgery, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea jh_cho@chonnam.ac.kr drydh@chonnam.ac.kr songsangyun@gmail.com.
Deok Hwan YangDepartment of Internal Medicine, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea jh_cho@chonnam.ac.kr drydh@chonnam.ac.kr songsangyun@gmail.com.
Jae-Ho ChoDepartment of Microbiology and Immunology, Chonnam National University Medical School, Hwasunup, Jeollanamdo, Republic of Korea jh_cho@chonnam.ac.kr drydh@chonnam.ac.kr songsangyun@gmail.com.ORCID 0000-0002-3081-7674
Chonnam National University Hwasun Hospital · KRPohang University of Science and Technology · KRChonnam National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCD8

methodsWe analyzed primary tumors and peripheral blood samples from 26 patients with non-small cell lung cancer and analyzed their phenotypes and functional characteristics using flow cytometry, RNA-sequencing, and bioinformatics.

resultsWe found that tumor-infiltrating Temra (tilTemra) cells largely differ from peripheral blood Temra (pTemra), with distinct transcriptomes and functional properties. Notably, although majority of the pTemra was CD27

conclusionsThese data suggest a complex interplay between CD8

Indexed as

Antigens, NeoplasmCarcinoma, Non-Small-Cell LungCD8-Positive T-LymphocytesCell DifferentiationHumansImmunotherapyLung NeoplasmsLymphocytes, Tumor-InfiltratingAntigens, NeoplasmbiomarkersCD8-positive T-lymphocytesimmunotherapylymphocytestumortumor-infiltrating

Identifiers

PMID34593620
PMCPMC8487216
OpenAlexW3203536646

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.