ReviewFrontiers in genetics2021
Modularity in Biological Networks.
Review in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Metabolic robustness is an emergent property of hierarchical network organization in yeast.mSystems · 2026Article
- Review
- Loss of long-range co-expression is a common feature in cancer.NPJ systems biology and applications · 2026Article
- Disentangling Arachis response to biotic and abiotic stress using multi-transcriptomics integration.BMC plant biology · 2026Article
- RePo index: a multidimensional framework to quantify genetic resilience in data-limited amphibian faunas.BMC genomics · 2026Article
- Format-Preserving Reduction of Canonical Nonlinear Models.Bulletin of mathematical biology · 2026Article
- Decoding the dark genome reveals its organisation into modular disease networks.Scientific reports · 2026Article
- Temporal network analysis in systems biology: concepts, inference, and validation.Frontiers in bioinformatics · 2026Review
- Functional Interpretation of Omics Data: From Pathways to Networks.Advances in experimental medicine and biology · 2026Review
- Bioinks in systems biology: integrating biomaterial design with cellular network modelling for predictive biofabrication.Frontiers in bioengineering and biotechnology · 2026Review
- An Introduction to Network Analysis in Plant Biology.Plant direct · 2025Article
- Chemical composition of floral perfumes in Mormodes (Orchidaceae): implications for selective attraction of euglossine bees.Annals of botany · 2025Article
- Prediction of new candidate proteins and analysis of sub-modules and protein hubs associated with seed development in rice (Oryza sativa) using an ensemble network-based systems biology approach.BMC plant biology · 2025Article
- Multi-Metric Approach for the Comparison of Denoising Techniques for Resting-State fMRI.Human brain mapping · 2025Article
- Gene Co-Expression Analysis Reveals Functional Differences Between Early- and Late-Onset Alzheimer's Disease.Current issues in molecular biology · 2025Article
- Accelerating crop improvement via integration of transcriptome-based network biology and genome editing.Planta · 2025Review
- Differential Transcriptional Programs Reveal Modular Network Rearrangements Associated with Late-Onset Alzheimer's Disease.International journal of molecular sciences · 2025Article
- Article
- The modular mind and psychiatry: toward clinical integration with a focus on self-disorders.Frontiers in psychology · 2025Article
- Microbial composition, assembly, and functional characteristics of generalized and specialized subcommunities under flooded paddy fields: long-term pesticide versus non-pesticide models.Frontiers in microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Network modeling, from the ecological to the molecular scale has become an essential tool for studying the structure, dynamics and complex behavior of living systems. Graph representations of the relationships between biological components open up a wide variety of methods for discovering the mechanistic and functional properties of biological systems. Many biological networks are organized into a modular structure, so methods to discover such modules are essential if we are to understand the biological system as a whole. However, most of the methods used in biology to this end, have a limited applicability, as they are very specific to the system they were developed for. Conversely, from the statistical physics and network science perspective, graph modularity has been theoretically studied and several methods of a very general nature have been developed. It is our perspective that in particular for the modularity detection problem, biology and theoretical physics/network science are less connected than they should. The central goal of this review is to provide the necessary background and present the most applicable and pertinent methods for community detection in a way that motivates their further usage in biological research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.