Evidence map›Paper›PMID 34599158›Full record

ArticleNature communications2021

Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids.

Jeff R Jones, Sneha Chaturvedi, Daniel Granados-Fuentes, Erik D Herzog

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 135 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. A direct SCN-to-DMH output pathway organizes circadian behavioral timing.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Selective and differential roles of PVHNature communications · 2026
    Article
  13. Alcohol and Opioids Modulate Excitatory Inputs to the SCN.bioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jeff R JonesDepartment of Biology, Washington University, St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-8386-7798
Sneha ChaturvediDepartment of Biology, Washington University, St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-2452-3685
Daniel Granados-FuentesDepartment of Biology, Washington University, St. Louis, St. Louis, MO, USA.
Erik D HerzogDepartment of Biology, Washington University, St. Louis, St. Louis, MO, USA. herzog@wustl.edu.ORCID http://orcid.org/0000-0001-7209-5174
Washington University in St. Louis · US

Funding

Collaborative Research: Inferring Dynamic Topology to Decode and Control Spatiotemporal Structures in Complex NetworksR01GM131403 · NIGMS · WASHINGTON UNIVERSITY · PI LI, JR-SHIN · 2018 to 2021
$1.6M
Hypocretinergic integration of circadian rhythms and sleepF32HL133772 · NHLBI · WASHINGTON UNIVERSITY · PI JONES, JEFFREY R · 2016 to 2018
$173k
NHLBI NIH HHS F32 HL133772NIGMS NIH HHS R01 GM131403
6 · The paper itself

Abstract

Signals from the central circadian pacemaker, the suprachiasmatic nucleus (SCN), must be decoded to generate daily rhythms in hormone release. Here, we hypothesized that the SCN entrains rhythms in the paraventricular nucleus (PVN) to time the daily release of corticosterone. In vivo recording revealed a critical circuit from SCN vasoactive intestinal peptide (SCN

Indexed as

AnimalsCalciumCircadian RhythmCLOCK ProteinsCorticosteroneCorticotropin-Releasing HormoneFecesGene Expression RegulationGene SilencingGlucocorticoidsMiceMice, Inbred C57BLMice, TransgenicNeuronsParaventricular Hypothalamic NucleusPhotometryCalciumCLOCK ProteinsCorticosteroneCorticotropin-Releasing HormoneGlucocorticoids

Identifiers

PMID34599158
PMCPMC8486846
OpenAlexW3203134377

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.