Evidence map›Paper›PMID 34600481›Full record

ArticleBMC cardiovascular disorders2021

Structural heart defects associated with ET

Ko-Chin Chen, Ko-Chien Chen, Zan-Min Song, Geoffrey D Croaker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Ko-Chin ChenAustralian National University Medical School, Florey Building 54 Mills Road, Acton, ACT, 2601, Australia. ckochin@gmail.com.ORCID 0000-0002-6650-1807
Ko-Chien ChenMD Anderson Cancer Centre, University of Texas, Houston, TX, 77030, USA.
Zan-Min SongThe John Curtin School of Medical Research, Australian National University Medical School, Acton, ACT, 2601, Australia.
Geoffrey D CroakerAustralian National University Medical School, Florey Building 54 Mills Road, Acton, ACT, 2601, Australia.
Australian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHSCR, a colonic neurocristopathy affecting 1/5000 births, is suggested to associate with cardiac septal defects and conotruncal malformations. However, we question subtle cardiac changes maybe more commonly present due to multi-regulations by HSCR candidate genes, in this instance, ET

methodsEleven neonatal rats were generated from heterozygote (ET

resultsCardiac morphology and constituents were preserved. However, significant volumetric reductions were recorded in sl/sl rats with respect to the control: whole heart (38.70%, p value = 0.02); LV (41.22%, p value = 0.01), RV (46.15%, p value = 0.02), LA (44.93%, p value = 0.06), and RA (39.49%, p value = 0.02). Consistent trend was observed in growth rate (~ 20%) and organ-volume/bodyweight ratios (~ 25%). On the contrary, measurements on aortic arch demonstrated no significant difference among the two groups.

conclusionDespite the presence of normal morphology, significant cardiac growth retardation was detected in sl/sl rat, supporting the likely association of cardiac anomalies with HSCR, at least in ET

Indexed as

AnimalsAnimals, NewbornDisease Models, AnimalGenetic Predisposition to DiseaseHeartHeart Defects, CongenitalHirschsprung DiseaseMutationMyocardiumRatsRats, TransgenicReceptor, Endothelin BWeight GainX-Ray Microtomographyednrb protein, ratReceptor, Endothelin BEndothelin-B mutationHeart defectsHirschsprung diseaseSpotting-lethal rat

Identifiers

PMID34600481
PMCPMC8487587
OpenAlexW3203952482

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.