ArticleProceedings of the National Academy of Sciences of the United States of America1986
Apolipoprotein B synthesis by human liver and intestine in vitro.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 129 citations in OpenAlex.
- Technologies for Targeted RNA Degradation and Induced RNA Decay.Chemical reviews · 2024Review
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- Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species.Nature communications · 2023Article
- The Expression of Myoz1 and ApoB is Positively Correlated with Meat Quality of Broiler Chicken.Veterinary medicine international · 2022Article
- Two apolipoproteins in salmon louse (Biochemistry and biophysics reports · 2021Article
- The Importance of Lipoprotein Lipase Regulation in Atherosclerosis.Biomedicines · 2021Review
- Effects of ammonia on growth performance, lipid metabolism and cecal microbial community of rabbits.PloS one · 2021Article
- Endoplasmic reticulum quality control in lipoprotein metabolism.Molecular and cellular endocrinology · 2019Review
- APOBEC3s: DNA-editing human cytidine deaminases.Protein science : a publication of the Protein Society · 2019Review
- Article
- Intestinal lymphatic transport for drug delivery.Advanced drug delivery reviews · 2011Review
- KIT is required for hepatic function during mouse post-natal development.BMC developmental biology · 2007Article
- Microsomal triglyceride transfer protein expression in mouse intestine.Histochemistry and cell biology · 2005Article
- Regulatable liver expression of the rabbit apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC-1) in mice lacking endogenous APOBEC-1 leads to aberrant hyperediting.The Biochemical journal · 2003Article
- Regulation of lipoprotein metabolism by estrogen in inbred strains of mice occurs primarily by posttranscriptional mechanisms.Molecular and cellular biochemistry · 1997Article
- Elevated triglyceride-rich lipoproteins in diabetes. A study of apolipoprotein B-48.Acta diabetologica · 1996Article
- Lipid and apolipoprotein B48 transport in mesenteric lymph and the effect of hyperphagia on the clearance of chylomicron-like emulsions in insulin-deficient rats.Diabetologia · 1994Article
- Recent advances in lipoprotein and atherosclerosis research at Baylor College of Medicine. Apolipoprotein B, lipoprotein[a], and transplantation arteriopathy.Texas Heart Institute journal · 1994Review
- Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.The Journal of clinical investigation · 1991Article
- Biosynthetic precursor (214 kDa) of apolipoprotein B-48 is not secreted by Caco-2 cells and normal human intestine.The Biochemical journal · 1989Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The synthesis of apolipoprotein B (apoB) was examined in human fetal and adult intestine and liver. Intestine and liver were minced and then incubated with [3H]leucine, homogenized, and subjected to immunoprecipitation with antiserum that recognized both apoB-100 and apoB-48 (forms of apoB found in low density lipoproteins and in chylomicrons, respectively). Immunoprecipitates of fetal and adult liver contained radioactivity in a single apoB-100 peak when examined by NaDodSO4/polyacrylamide gel electrophoresis. Intestine from fetuses at 11 weeks of gestation incorporated radioactivity mainly into apoB-100, with little incorporation into apoB-48. Sixteen-week fetal intestine showed both apoB-100 and apoB-48, whereas adult intestine incorporated radioactivity only into apoB-48. Pulse-chase experiments with 11- and 16-week fetal intestine showed no evidence for the conversion of apoB-100 to apoB-48. Incubation of intestinal homogenates with fetal liver apoB-100 did not result in the conversion of apoB-100 to smaller forms of apoB. A cDNA probe to hepatic apoB-100 identified a single, 18-kilobase transcript in poly(A)+ RNA from fetal and adult liver and fetal intestine of all ages. These studies define the developmental pattern of apoB synthesis in human fetal and adult liver and intestine. No evidence could be found for the conversion of apoB-100 to apoB-48. The finding of a single mRNA transcript despite the form of apoB synthesized in each tissue is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.