Evidence map›Paper›PMID 34605694›Full record

ArticleJournal of diabetes science and technology2022

Continuous Ketone Monitoring Consensus Report 2021.

Kevin T Nguyen, Nicole Y Xu, Jennifer Y Zhang, Trisha Shang, Ananda Basu, Richard M Bergenstal, Kristin Castorino, Kong Y Chen, David Kerr, Suneil K Koliwad and 14 more

Registry-linked trialOpen access · bronzeAbstract readConsensus Statement
In one paragraph

Article in Journal of diabetes science and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03508934 (Continuous Glucose Monitoring in Insulin Treated Hospitalized Veterans With DM2 at Higher Risk for Hypoglycemia), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03508934 naactive not recruitingnot on this map

Continuous Glucose Monitoring in Insulin Treated Hospitalized Veterans With DM2 at Higher Risk for Hypoglycemia

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2018 to 2026Enrolled218ConditionsDiabetes Mellitus, Type 2, HypoglycemiaArmsGTS (Continuous Glucose Monitoring), POC (Point of Care)
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Update on Measuring Ketones.Journal of diabetes science and technology · 2024
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Roadmap to the Effective Use of Continuous Glucose Monitoring: Innovation, Investigation, and Implementation.Diabetes spectrum : a publication of the American Diabetes Association · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 18 institutions in 1 country.

Kevin T NguyenDiabetes Technology Society, Burlingame, CA, USA.ORCID 0000-0001-9102-6537
Nicole Y XuDiabetes Technology Society, Burlingame, CA, USA.ORCID 0000-0001-9353-8819
Jennifer Y ZhangDiabetes Technology Society, Burlingame, CA, USA.ORCID 0000-0002-3374-9777
Trisha ShangDiabetes Technology Society, Burlingame, CA, USA.ORCID 0000-0001-9687-9336
Ananda BasuUniversity of Virginia, Charlottesville, VA, USA.
Richard M BergenstalInternational Diabetes Center, Minneapolis, MN, USA.ORCID 0000-0002-9050-5584
Kristin CastorinoSansum Diabetes Research Institute, Santa Barbara, CA, USA.ORCID 0000-0001-6386-9203
Kong Y ChenNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.ORCID 0000-0002-0306-1904
David KerrSansum Diabetes Research Institute, Santa Barbara, CA, USA.ORCID 0000-0003-1335-1857
Suneil K KoliwadUniversity of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-7367-1054
Lori M LaffelJoslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-9675-3001
Nestoras MathioudakisJohns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0210-655X
L Kurt MidyettMidwest Pediatric Specialists, Overland Park, KS, USA.ORCID 0000-0001-8486-7370
Joshua D MillerStony Brook University, Stony Brook, NY, USA.ORCID 0000-0001-9512-461X
James H NicholsVanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-3652-1612
Francisco J PasquelEmory University, Atlanta, GA, USA.ORCID 0000-0002-3845-6703
Priya PrahaladStanford University, Stanford, CA, USA.
Mark R PrausnitzGeorgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-9076-8448
Jane Jeffrie SeleyWeill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-1582-4320
Jennifer L SherrYale University, New Haven, CT, USA.ORCID 0000-0001-9301-3043
Elias K SpanakisBaltimore Veterans Affairs Medical Center, Baltimore, MD, USA.ORCID 0000-0002-9352-7172
Guillermo E UmpierrezEmory University, Atlanta, GA, USA.ORCID 0000-0002-3252-5026
Amisha WalliaNorthwestern University, Chicago, IL, USA.ORCID 0000-0002-3183-4062
David C KlonoffMills-Peninsula Medical Center, San Mateo, CA, USA.ORCID 0000-0001-6394-6862
Diabetes Technology Society · USEmory University · USSansum Diabetes Research Institute · USAdult and Pediatric Dermatology · USCornell University · USGeorgia Institute of Technology · USJohns Hopkins University · USJoslin Diabetes Center · USMills Peninsula Health Services · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNorthwestern University · USStanford University · USStony Brook University · USUniversity of California, San Francisco · USUniversity of Maryland, Baltimore · USUniversity of Virginia · USVanderbilt University Medical Center · USYale University · US

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Translational Research Core - Engagement and Behavior ChangeP30DK111024 · NIDDK · EMORY UNIVERSITY · PI Mohammed Kumail Ali · 2016 to 2026
$13.4M
Metabolic Phenotyping During Stress Hyperglycemia in Cardiac Surgery PatientsK23GM128221 · NIGMS · EMORY UNIVERSITY · PI PASQUEL, FRANCISCO J · 2018 to 2022
$957k
Continuous Glucose Monitoring in Insulin Treated Hospitalized Veterans with DM2 at Higher Risk for HypoglycemiaI01CX001825 · VA · BALTIMORE VA MEDICAL CENTER · PI SPANAKIS, ILIAS · 2018 to 2023
–
CSRD VA I01 CX001825NIDDK NIH HHS P30 DK045735NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIDDK NIH HHS P30 DK111024NIGMS NIH HHS K23 GM128221
6 · The paper itself

Abstract

This article is the work product of the Continuous Ketone Monitoring Consensus Panel, which was organized by Diabetes Technology Society and met virtually on April 20, 2021. The panel consisted of 20 US-based experts in the use of diabetes technology, representing adult endocrinology, pediatric endocrinology, advanced practice nursing, diabetes care and education, clinical chemistry, and bioengineering. The panelists were from universities, hospitals, freestanding research institutes, government, and private practice. Panelists reviewed the medical literature pertaining to ten topics: (1) physiology of ketone production, (2) measurement of ketones, (3) performance of the first continuous ketone monitor (CKM) reported to be used in human trials, (4) demographics and epidemiology of diabetic ketoacidosis (DKA), (5) atypical hyperketonemia, (6) prevention of DKA, (7) non-DKA states of fasting ketonemia and ketonuria, (8) potential integration of CKMs with pumps and automated insulin delivery systems to prevent DKA, (9) clinical trials of CKMs, and (10) the future of CKMs. The panelists summarized the medical literature for each of the ten topics in this report. They also developed 30 conclusions (amounting to three conclusions for each topic) about CKMs and voted unanimously to adopt the 30 conclusions. This report is intended to support the development of safe and effective continuous ketone monitoring and to apply this technology in ways that will benefit people with diabetes.

Indexed as

Diabetic KetoacidosisKetosisAdultChildHumansKetonesMonitoring, PhysiologicKetonesacetoacetatecontinuousketoacidosisketoneβ-hydroxybutyrate

Identifiers

PMID34605694
PMCPMC9294575
OpenAlexW3204768502

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.