Evidence map›Paper›PMID 34605719›Full record

ArticleEpigenetics2022

CD4

Tejaswi V Badam, Sandra Hellberg, Ratnesh B Mehta, Jeannette Lechner-Scott, Rodney A Lea, Jorg Tost, Xavier Mariette, Judit Svensson-Arvelund, Colm E Nestor, Mikael Benson and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Prominent epigenetic and transcriptomic changes in CD4Journal of neuroinflammation · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Tejaswi V BadamBioinformatics Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.
Sandra HellbergBioinformatics Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.ORCID 0000-0002-8713-7434
Ratnesh B MehtaDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Jeannette Lechner-ScottSchool of Medicine and Public Health, University of Newcastle, Callaghan, Australia.
Rodney A LeaSchool of Medicine and Public Health, University of Newcastle, Callaghan, Australia.
Jorg TostLaboratory of Epigenetics and Environment, Centre National De Recherche En Génomique Humaine, CEA-Institut De Biologie Francois Jacob, Evry, France.ORCID 0000-0002-2683-0817
Xavier MarietteUniversité Paris-Saclay, AP-HP-Université Paris-Saclay, Hôpital Bicêtre, Institut National de la Santé et de la Recherche Médicale (Inserm) U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, France.
Judit Svensson-ArvelundDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Colm E NestorThe Centre for Individualized Medicine, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Mikael BensonThe Centre for Individualized Medicine, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Göran BergDepartment of Obstetrics and Gynaecology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Maria C JenmalmDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Mika GustafssonBioinformatics Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.ORCID 0000-0002-0048-4063
Jan ErnerudhDepartment of Clinical Immunology and Transfusion Medicine and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Linköping University · SECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInserm · FRJohn Hunter Hospital · AUQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetics may play a central, yet unexplored, role in the profound changes that the maternal immune system undergoes during pregnancy and could be involved in the pregnancy-induced modulation of several autoimmune diseases. We investigated changes in the methylome in isolated circulating CD4

Indexed as

Arthritis, RheumatoidAutoimmune DiseasesLupus Erythematosus, SystemicMultiple SclerosisCD28 AntigensCD4-Positive T-LymphocytesDNA MethylationFemaleGenome-Wide Association StudyHumansLeukocytes, MononuclearPhosphatesPregnancyT-LymphocytesCD28 AntigensPhosphatesCD4+ T cellsepigeneticsmethylationmodulemultiple sclerosisPregnancyrheumatoid arthritissystemic lupus erythematosus

Identifiers

PMID34605719
PMCPMC9487751
OpenAlexW3204221499

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.