Evidence map›Paper›PMID 34606040›Full record

ArticleGeroScience2022

Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for White Matter and Cognition.

Shawn N Whitehead, Askiel Bruno, Jeffrey M Burns, S Thomas Carmichael, Anna Csiszar, Jodi D Edwards, Fanny M Elahi, Giuseppe Faraco, Douglas B Gould, Deborah R Gustafson and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in GeroScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Novel intravital approaches to quantify deep vascular structure and perfusion in the aging mouse brain using ultrasound localization microscopy (ULM).Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 17 institutions in 4 countries.

Shawn N WhiteheadDepartment of Anatomy and Cell Biology, Western University, London, ON, N6A 3K7, Canada. shawn.whitehead@schulich.uwo.ca.
Askiel BrunoDepartment of Neurology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Jeffrey M BurnsDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
S Thomas CarmichaelDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Anna CsiszarVascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Jodi D EdwardsUniversity of Ottawa Heart Institute, Ottawa, Canada.
Fanny M ElahiMemory and Aging Center, UCSF Weill Institute for Neurosciences, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
Giuseppe FaracoFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10065, USA.
Douglas B GouldDepartments of Ophthalmology and Anatomy, and Institute for Human Genetics, School of Medicine, University of California, San Francisco, 94143, USA.
Deborah R GustafsonDepartment of Neurology, Section for NeuroEpidemiology, State University of New York Downstate Health Sciences University, New York, Brooklyn, 11203, USA.
Vladimir HachinskiDepartment of Clinical Neurological Sciences, Western University, London, ON, N6A 5C1, Canada.
Gary RosenbergUNM Health Sciences Center, University of New Mexico, Albuquerque, NM, 87106, USA.
Farzaneh A SorondDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Andy Y ShihCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute; Department of Pediatrics; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Kai Hei TseDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Zoltan UngvariVascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Donna M WilcockSanders-Brown Center on Aging; Department of Neurology, Department of Behavioral Science, University of Kentucky, Lexington, KY, 40536, USA.
Kristen L ZuloagaDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, 12208, USA.
Frank C BaroneDepartment of Neurology, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA.
Semmelweis University · HUWestern University · CAAlbany Medical Center Hospital · USAugusta University · USCenter for Neurosciences · USHong Kong Polytechnic University · HKMIND Research Institute · USNorthwestern University · USState University of New York · USSUNY Downstate Health Sciences University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Kansas Medical Center · USUniversity of Kentucky · USUniversity of New Mexico · USUniversity of Ottawa · CAUniversity of Washington · US

Funding

Cerebral microhemorrhages and gait dysfunction in agingR01AG055395 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA · 2017 to 2025
$2.3M
Age-related vascular cognitive impairment: role of endothelial senescenceR01AG068295 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA, UNGVARI, ZOLTAN ISTVAN · 2020 to 2024
$1.8M
Cerebromicrovascular rejuvenation by heterochronic blood exchangeRF1AG072295 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA, UNGVARI, ZOLTAN ISTVAN · 2021 to 2021
$1.4M
NIA NIH HHS R01 AG055395NIA NIH HHS R01 AG068295NIA NIH HHS RF1 AG072295
6 · The paper itself

Abstract

White matter pathologies are critically involved in the etiology of vascular cognitive impairment-dementia (VCID), Alzheimer's disease (AD), and Alzheimer's disease and related diseases (ADRD), and therefore need to be considered a treatable target ( Roseborough A, Hachinski V, Whitehead S. White matter degeneration - a treatable target? Roseborough et al. JAMA Neurol [Internet]. 2020 Apr 27;77(7):793-4, [1] . To help address this often-missed area of research, several workshops have been sponsored by the Leo and Anne Albert Charitable Trust since 2015, resulting in the incorporation of "The Albert Research Institute for White Matter and Cognition" in 2020. The first annual "Institute" meeting was held virtually on March 3-4, 2021. The Institute provides a forum and workspace for communication and support of the advancement of white matter science and research to better understand the evolution and prevention of dementia. It serves as a platform for young investigator development, to introduce new data and debate biology mechanisms and new ideas, and to encourage and support new research collaborations and directions to clarify how white matter changes, with other genetic and health risk factors, contribute to cognitive impairment. Similar to previous Albert Trust-sponsored workshops (Barone et al. in J Transl Med 14:1-14, [2]; Sorond et al. in GeroScience 42:81-96, [3]), established expert investigators were identified and invited to present. Opportunities to attend and present were also extended by invitation to talented research fellows and younger scientists. Also, updates on institute-funded research collaborations were provided and discussed. The summary that follows is a synopsis of topics and discussion covered in the workshop.

Indexed as

Dementia, VascularLeukoencephalopathiesWhite MatterAcademies and InstitutesCognitionHumansADCognitionNeurodegenerative disease/injuryVCIDWhite matter

Identifiers

PMID34606040
PMCPMC8488071
OpenAlexW3203992211

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.