Evidence map›Paper›PMID 34608550›Full record

ArticleMolecular diversity2022

Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies.

Hina Siddiqui, M A A Baheej, Saeed Ullah, Fazila Rizvi, Shazia Iqbal, Haroon M Haniffa, Atia-Tul Wahab, M Iqbal Choudhary

Abstract read
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In one paragraph

Article in Molecular diversity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Meldrum-Based-1ACS omega · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hina SiddiquiH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. hinahej@gmail.com.
M A A BaheejDepartment of Chemical Sciences, Faculty of Applied Sciences, South Eastern University, Oluvil, Sri Lanka.
Saeed UllahDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Fazila RizviH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Shazia IqbalH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Haroon M HaniffaDepartment of Chemical Sciences, Faculty of Applied Sciences, South Eastern University, Oluvil, Sri Lanka.
Atia-Tul WahabDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
M Iqbal ChoudharyH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. hej@cyber.net.pk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current study was aimed to discover potent inhibitors of α-glucosidase enzyme. A 25 membered library of new 1,2,3-triazole derivatives of hydrochlorothiazide (1) (HCTZ, a diuretic drug also being used for the treatment of high blood pressure) was synthesized through click chemistry approach. The structures of all derivatives 2-26 were deduced by MS, IR,

Indexed as

Glycoside Hydrolase InhibitorsHydrochlorothiazideTriazolesalpha-GlucosidasesAnimalsClick ChemistryKineticsMiceMolecular Docking SimulationMolecular StructureStructure-Activity Relationshipalpha-GlucosidasesGlycoside Hydrolase InhibitorsHydrochlorothiazideTriazoles1,2,3-Triazole derivativesClick chemistryCytotoxicityDiabetesHydrochlorothiazideα-Glucosidase enzyme

Identifiers

PMID34608550

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.