Evidence map›Paper›PMID 34609638›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2021

The role of glucocorticoid receptor gene in the association between attention deficit-hyperactivity disorder and smaller brain structures.

Cibele E Bandeira, Eugenio H Grevet, Renata B Cupertino, Maria E de Araujo Tavares, Clara S Gusmão, Djenifer B Kappel, Eduardo S Vitola, Felipe A Picon, Luís A Rohde, Bruna S da Silva and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Cibele E BandeiraDepartment of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Eugenio H GrevetADHD Outpatient Program, Adult Division, Hospital de Clínicas de Porto Alegre, Avenida Bento Gonçalves, 9500, Porto Alegre, RS, Brazil.
Renata B CupertinoDepartment of Psychiatry, University of Vermont, Burlington, VT, USA.
Maria E de Araujo TavaresDepartment of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Clara S GusmãoDepartamento de Fisiologia e Biofísica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, São Paulo, Brazil.
Djenifer B KappelDepartment of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Eduardo S VitolaADHD Outpatient Program, Adult Division, Hospital de Clínicas de Porto Alegre, Avenida Bento Gonçalves, 9500, Porto Alegre, RS, Brazil.
Felipe A PiconADHD Outpatient Program, Adult Division, Hospital de Clínicas de Porto Alegre, Avenida Bento Gonçalves, 9500, Porto Alegre, RS, Brazil.
Luís A RohdeDepartament of Psychiatry, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Bruna S da SilvaDepartment of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Claiton H D Bau *Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. claiton.bau@ufrgs.br.
Diego L Rovaris *ADHD Outpatient Program, Adult Division, Hospital de Clínicas de Porto Alegre, Avenida Bento Gonçalves, 9500, Porto Alegre, RS, Brazil. drovaris@usp.br.ORCID 0000-0002-8910-4927
Universidade Federal do Rio Grande do Sul · BRUniversidade de São Paulo · BRUniversity of Vermont · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ADHD is associated with smaller subcortical brain volumes and cortical surface area, with greater effects observed in children than adults. It is also associated with dysregulation of the HPA axis. Considering the effects of the glucocorticoid receptor (NR3C1) in neurophysiology, we hypothesize that the blurred relationships between brain structures and ADHD in adults could be partly explained by NR3C1 gene variation. Structural T1-weighted images were acquired on a 3 T scanner (N = 166). Large-scale genotyping was performed, and it was followed by quality control and pruning procedures, which resulted in 48 independent NR3C1 gene variants analyzed. After a stringent Bonferroni correction, two SNPs (rs2398631 and rs72801070) moderated the association between ADHD and accumbens and amygdala volumes in adults. The significant SNPs that interacted with ADHD appear to have a role in gene expression regulation, and they are in linkage disequilibrium with NR3C1 variants that present well-characterized physiological functions. The literature-reported associations of ADHD with accumbens and amygdala were only observed for specific NR3C1 genotypes. Our findings reinforce the influence of the NR3C1 gene on subcortical volumes and ADHD. They suggest a genetic modulation of the effects of a pivotal HPA axis component in the neuroanatomical features of ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityReceptors, GlucocorticoidAdultBrainGlucocorticoidsHumansHypothalamo-Hypophyseal SystemMagnetic Resonance ImagingPituitary-Adrenal SystemGlucocorticoidsNR3C1 protein, humanReceptors, GlucocorticoidAmygdalaAttention deficit-hyperactivity disorderGlucocorticoid receptorNeuroimagingNucleus accumbens

Identifiers

PMID34609638
OpenAlexW3202253309

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.