Evidence map›Paper›PMID 34609965›Full record

ArticleJCI insight2021

NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant.

Harry Pickering, Subha Sen, Janice Arakawa-Hoyt, Kenichi Ishiyama, Yumeng Sun, Rajesh Parmar, Richard S Ahn, Gemalene Sunga, Megan Llamas, Alexander Hoffmann and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Progress in the mechanistic understanding of NETs formation in cancer.Medical oncology (Northwood, London, England) · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Autophagic regulation of CD8Frontiers in cellular and infection microbiology · 2025
    Article
  12. Observational
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Pre-Transplant Frequencies of FoxP3Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  20. Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Harry PickeringDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Subha SenDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Janice Arakawa-HoytDepartment of Microbiology and Immunology, Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, California, USA.
Kenichi IshiyamaDepartment of Microbiology and Immunology, Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, California, USA.
Yumeng SunDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Rajesh ParmarDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Richard S AhnMicrobiology, Immunology, and Molecular Genetics.
Gemalene SungaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Megan LlamasDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Alexander HoffmannInstitute for Quantitative and Computational Biosciences, and.
Mario DengDivision of Infectious Diseases, Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Suphamai BunnapradistDivision of Nephrology, David Geffen School of Medicine, Los Angeles, California, USA.
Joanna M SchaenmanDivision of Infectious Diseases, Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
David W GjertsonDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Maura RossettiDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Lewis L LanierDepartment of Microbiology and Immunology, Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, California, USA.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
CMV Systems Immunobiology Group
University of California, Los Angeles · USParker Institute for Cancer Immunotherapy · USQuantitative BioSciences · US

Funding

Project 3: Mapping the Evolution of Chronic Transplant Injury in the Context of CMV InfectionU19AI128913 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOFFMANN, ALEXANDER · 2017 to 2021
$11.2M
Cell decision underlying B-cell immune responsesR01AI132731 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOFFMANN, ALEXANDER · 2018 to 2022
$2.2M
NIAID NIH HHS R01 AI132731NIAID NIH HHS U19 AI128913
6 · The paper itself

Abstract

CMV causes mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals can be life-threatening. CMV viremia often occurs in solid organ transplant recipients and associates with decreased graft survival and higher mortality. Furthering understanding of impaired immunity that allows CMV reactivation is critical to guiding antiviral therapy and examining the effect of CMV on solid organ transplant outcomes. This study characterized longitudinal immune responses to CMV in 31 kidney transplant recipients with CMV viremia and matched, nonviremic recipients. Recipients were sampled 3 and 12 months after transplant, with additional samples 1 week and 1 month after viremia. PBMCs were stained for NK and T cell markers. PBMC transcriptomes were characterized by RNA-Seq. Plasma proteins were quantified by Luminex. CD8+ T cell transcriptomes were characterized by single-cell RNA-Seq. Before viremia, patients had high levels of IL-15 with concurrent expansion of immature CD56bright NK cells. After viremia, mature CD56dim NK cells and CD28-CD8+ T cells upregulating inhibitory and NK-associated receptors were expanded. Memory NK cells and NK-like CD28-CD8+ T cells were associated with control of viremia. These findings suggest that signatures of innate activation may be prognostic for CMV reactivation after transplant, while CD8+ T cell functionality is critical for effective control of CMV.

Indexed as

AdultAgedCD8-Positive T-LymphocytesCytomegalovirus InfectionsFemaleHumansKidney TransplantationKiller Cells, NaturalMaleMiddle AgedPhenotypeViremiaYoung AdultImmunologyNK cellsOrgan transplantationT cellsTransplantation

Identifiers

PMID34609965
PMCPMC8663544
OpenAlexW3204797197

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.