Evidence mapPaperPMID 34611531Full record

ArticleNeurobiology of stress2021

Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition.

Carolina Muniz Carvalho, Frank R Wendt, Gita A Pathak, Adam X Maihofer, Dan J Stein, Jennifer A Sumner, Sian M J Hemmings, Caroline M Nievergelt, Karestan C Koenen, Joel Gelernter and 2 more

Abstract read
In one paragraph

Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Genetic pleiotropy differentially linking brain variation to cannabis use and cannabis use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome.medRxiv : the preprint server for health sciences · 2023
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carolina Muniz CarvalhoDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, 06516, USA.
Frank R WendtDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, 06516, USA.
Gita A PathakDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, 06516, USA.
Adam X MaihoferDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Dan J SteinMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Jennifer A SumnerDepartment of Psychology, University of California, Los Angeles, CA, USA.
Sian M J HemmingsDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Caroline M NievergeltDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, United States.
Joel GelernterDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, 06516, USA.
Sintia I BelangeroDepartment of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Renato PolimantiDepartment of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, 06516, USA.

Funding

TRAINING IN PSYCHIATRIC EPIDEMIOLOGY/BIOSTATISTICST32MH017119 · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · 1985 to 2005
$3.0M
4/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124847 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$366k
Psychiatric Genomics Consortium for PTSDR01MH106595 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$205k
BLRD VA I01 BX006482CSRD VA I01 CX001849Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NIDA NIH HHS R21 DA047527NIDCD NIH HHS R21 DC018098NIMH NIH HHS F32 MH122058NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH124847NIMH NIH HHS T32 MH017119
6 · The paper itself

Abstract

There is a well-known association of traumatic experiences and posttraumatic stress disorder (PTSD) with body size and composition, including consistent differences between sexes. However, the biology underlying these associations is unclear. To understand the genetic underpinnings of this complex relationship, we investigated genome-wide datasets informative of African and European ancestries from the Psychiatric Genomic Consortium, the UK Biobank, the GIANT Consortium, and the Million Veteran Program. We used genome-wide association statistics to estimate sex-specific genetic correlations (

Indexed as

Anthropometric traitsMendelian randomizationPTSDSexTrauma

Identifiers

PMID34611531
PMCPMC8477211

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.