Evidence map›Paper›PMID 34611846›Full record

ArticleDrug delivery and translational research2021

Biomaterial-enabled induction of pancreatic-specific regulatory T cells through distinct signal transduction pathways.

Sean T Carey, Joshua M Gammon, Christopher M Jewell

Open access · greenAbstract read
In one paragraph

Article in Drug delivery and translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Synthetic organic materials for targeting immunotherapies to lymph nodes.Chemistry of materials : a publication of the American Chemical Society · 2024
    Article
  3. Review
  4. Review
  5. Engineering metabolism to modulate immunity.Advanced drug delivery reviews · 2024
    Review
  6. Epitope-based precision immunotherapy of Type 1 diabetes.Human vaccines & immunotherapeutics · 2023
    Article
  7. Review
  8. Biomaterial Strategies for Selective Immune Tolerance: Advances and Gaps.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  9. Article
  10. Overcoming transport barrier to immunotherapies.Drug delivery and translational research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Sean T CareyFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.
Joshua M GammonFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.
Christopher M JewellFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA. cmjewell@umd.edu.ORCID http://orcid.org/0000-0002-6668-6928
University of Maryland, College Park · USUniversity of Maryland, Baltimore · US

Funding

Harnessing biomaterials to study the link between local lymph node function and systemic toleranceR01EB026896 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI JEWELL, CHRISTOPHER M · 2018 to 2021
$1.5M
NIBIB NIH HHS R01 EB026896
6 · The paper itself

Abstract

Autoimmune diseases-where the immune system mistakenly targets self-tissue-remain hindered by non-specific therapies. For example, even molecularly specific monoclonal antibodies fail to distinguish between healthy cells and self-reactive cells. An experimental therapeutic approach involves delivery of self-molecules targeted by autoimmunity, along with immune modulatory signals to produce regulatory T cells (T

Indexed as

Diabetes Mellitus, Type 1T-Lymphocytes, RegulatoryBiocompatible MaterialsHumansLymphocyte ActivationSignal TransductionBiocompatible MaterialsAutoimmunityImmunotherapymTORNanoparticles and microparticlesNanotechnologyRetinoids

Identifiers

PMID34611846
PMCPMC8581478
OpenAlexW3202659851

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.