Evidence map›Paper›PMID 34612558›Full record

ArticleHuman brain mapping2022

The Enhancing NeuroImaging Genetics through Meta-Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping.

Paul M Thompson, Neda Jahanshad, Lianne Schmaal, Jessica A Turner, Anderson M Winkler, Sophia I Thomopoulos, Gary F Egan, Peter Kochunov

Open access · goldAbstract read
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  19. Large-Scale Neuroimaging of Mental Illness.Current topics in behavioral neurosciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Lianne SchmaalOrygen, Parkville, Australia.
Jessica A TurnerPsychology Department, Georgia State University, Atlanta, Georgia, USA.
Anderson M WinklerNational Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.ORCID 0000-0002-4169-9781
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.ORCID 0000-0002-0046-4070
Gary F EganMonash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia.
Peter KochunovDepartment of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3656-4281
University of Southern California · USGeorgia State University · USMonash University · AUNational Institutes of Health · USThe University of Melbourne · AUUniversity of Maryland, Baltimore · US

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Psychophysiological Precursors of AlcoholismR01AA012207 · NIAAA · UNIV OF ARKANSAS FOR MED SCIS · PI ACHESON, ASHLEY, KOCHUNOV, PETER V. · 2001 to 2025
$9.0M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
ENIGMA-COINSTAC-APOE2 Functional and structural connectome protective mechanisms for Alzheimer’s disease and mood disorders: Request for supplemental funds for NIH R01:1R01MH121246R01MH121246 · NIMH · OHIO STATE UNIVERSITY · PI CALHOUN, VINCE D, TURNER, JESS · 2019 to 2023
$5.0M
Towards Multisystem-Brain Successful Aging in Schizophrenia SpectrumR01MH116948 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HONG, L ELLIOT ELLIOT · 2018 to 2022
$3.7M
ENIGMA World Aging CenterR01AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2021 to 2025
$3.3M
Lifespan Vascular Biology on White MatterRF1NS114628 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2020 to 2020
$3.1M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
The Vascular Axis in Schizophrenia Brain-Body AgingR01MH133812 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI L Elliot Elliot Hong · 2024 to 2026
$2.2M
fMRI Study Of Risk Of Mood/Anxiety Disorders In ChildrenZ01MH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.7M
Intramural NIH HHS Z01 MH002781Intramural NIH HHS Z01 MH002782NIAAA NIH HHS R01 AA012207NIA NIH HHS R01 AG058854NIA NIH HHS R56 AG058854NIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NIH HHS R01 MH116147NIH HHS R56 AG058854NIH HHS S10 OD023696NIH HHS U54 EB020403NIH HHS ZIA-MH002781NIH HHS ZIA-MH002782NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH116948NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH121246NIMH NIH HHS R01 MH133812NIMH NIH HHS RF1 MH123163NINDS NIH HHS R01 NS114628NINDS NIH HHS RF1 NS114628
6 · The paper itself

Abstract

This Special Issue of Human Brain Mapping is dedicated to a 10-year anniversary of the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium. It reports updates from a broad range of international neuroimaging projects that pool data from around the world to answer fundamental questions in neuroscience. Since ENIGMA was formed in December 2009, the initiative grew into a worldwide effort with over 2,000 participating scientists from 45 countries, and over 50 working groups leading large-scale studies of human brain disorders. Over the last decade, many lessons were learned on how best to pool brain data from diverse sources. Working groups were created to develop methods to analyze worldwide data from anatomical and diffusion magnetic resonance imaging (MRI), resting state and task-based functional MRI, electroencephalography (EEG), magnetoencephalography (MEG), and magnetic resonance spectroscopy (MRS). The quest to understand genetic effects on human brain development and disease also led to analyses of brain scans on an unprecedented scale. Genetic roadmaps of the human cortex were created by researchers worldwide who collaborated to perform statistically well-powered analyses of common and rare genetic variants on brain measures and rates of brain development and aging. Here, we summarize the 31 papers in this Special Issue, covering: (a) technical approaches to harmonize analysis of different types of brain imaging data, (b) reviews of the last decade of work by several of ENIGMA's clinical and technical working groups, and (c) new empirical papers reporting large-scale international brain mapping analyses in patients with substance use disorders, schizophrenia, bipolar disorders, major depression, posttraumatic stress disorder, obsessive compulsive disorder, epilepsy, and stroke.

Indexed as

GeneticsMeta-Analysis as TopicMulticenter Studies as TopicNeuroimagingBrain MappingHumansbig dataDTIENIGMAgeneticsGWASinternational researchMRIneuroimagingneurosciencereproducibility

Identifiers

PMID34612558
PMCPMC8675422
OpenAlexW3203860994

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.