Evidence map›Paper›PMID 34613787›Full record

ArticleMolecular biology of the cell2022

Counting actin in contractile rings reveals novel contributions of cofilin and type II myosins to fission yeast cytokinesis.

Mamata Malla, Thomas D Pollard, Qian Chen

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Asymmetric distribution of actin-related proteins in the earlybioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Twist response of actin filaments.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Myosin turnover controls actomyosin contractile instability.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Mamata MallaDepartment of Biological Sciences, The University of Toledo, Toledo, OH 43606.
Thomas D PollardDepartments of Molecular Cellular and Developmental Biology.
Qian ChenDepartment of Biological Sciences, The University of Toledo, Toledo, OH 43606.
University of Toledo · USYale University · US

Funding

Mechanism of cytokinesis in fission yeastR01GM026132 · NIGMS · YALE UNIVERSITY · PI POLLARD, THOMAS D. · 1985 to 2021
$8.8M
Dendrite structure: Data-Driven Models to Bridge from Molecules to MorphologyR01NS118884 · NINDS · YALE UNIVERSITY · PI HOWARD, JONATHON · 2021 to 2025
$2.0M
The mechanism of cell size regulation by polycystinsR01GM144652 · NIGMS · UNIVERSITY OF TOLEDO · PI Qian Chen · 2022 to 2026
$1.6M
Microtubule Severing and Regrowth by SpastinR01GM139337 · NIGMS · YALE UNIVERSITY · PI HOWARD, JONATHON · 2020 to 2023
$1.3M
The molecular roles of polycystin in cytokinesisR15GM134496 · NIGMS · UNIVERSITY OF TOLEDO · PI CHEN, QIAN · 2019 to 2019
$444k
NIGMS NIH HHS R01 GM026132NIGMS NIH HHS R01 GM139337NIGMS NIH HHS R01 GM144652NIGMS NIH HHS R15 GM134496NINDS NIH HHS R01 NS118884
6 · The paper itself

Abstract

Cytokinesis by animals, fungi, and amoebas depends on actomyosin contractile rings, which are stabilized by continuous turnover of actin filaments. Remarkably little is known about the amount of polymerized actin in contractile rings, so we used low concentrations of GFP-Lifeact to count total polymerized actin molecules in the contractile rings of live fission yeast cells. Contractile rings of wild-type cells accumulated polymerized actin molecules at 4900/min to a peak number of ∼198,000 followed by a loss of actin at 5400/min throughout ring constriction. In

Indexed as

SchizosaccharomycesSchizosaccharomyces pombe ProteinsActin CytoskeletonActin Depolymerizing FactorsActinsAnimalsCytokinesisMyopiaMyosin Heavy ChainsMyosinsMyosin Type IIActin Depolymerizing FactorsActinsMYO2 protein, S pombeMyosin Heavy ChainsMyosinsMyosin Type IIMyp2 protein, S pombeSchizosaccharomyces pombe Proteins

Identifiers

PMID34613787
PMCPMC9265160
OpenAlexW3203559168

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.