Evidence map›Paper›PMID 34613843›Full record

ArticleAmerican journal of physiology. Cell physiology2021

Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles.

Diana L Torres-Pinzon, Donna L Ralph, Luciana C Veiras, Alicia A McDonough

Open access · hybridAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Sex differences in renal acid-base regulation.American journal of physiology. Renal physiology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
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  11. Flow-dependent transport processes 2024: filtration, absorption, and secretion.American journal of physiology. Renal physiology · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Epithelial NaComprehensive Physiology · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Diana L Torres-PinzonDepartment of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, California.
Donna L RalphDepartment of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, California.
Luciana C VeirasDepartment of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, California.
Alicia A McDonoughDepartment of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, California.ORCID 0000-0002-0459-469X
University of Southern California · US

Funding

Sodium transporter regulation during hypertensionR01DK083785 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AURELIE EDWARDS, Alicia A. McDonough · 2011 to 2026
$5.8M
REGULATION ON SODIUM PUMPS IN THE KIDNEYR01DK034316 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCDONOUGH, ALICIA A. · 1986 to 2008
$2.7M
Renal sodium handling in hypertension: impact of age, sex, and dietary potassiumR56DK123780 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EDWARDS, AURELIE, MCDONOUGH, ALICIA A. · 2020 to 2020
$98k
NIDDK NIH HHS R01 DK034316NIDDK NIH HHS R01 DK083785NIDDK NIH HHS R56 DK123780
6 · The paper itself

Abstract

Kidneys continuously filter an enormous amount of sodium and adapt kidney Na

Indexed as

Adaptation, PhysiologicalWater-Electrolyte BalanceAnimalsBiomarkersFemaleKidney Tubules, CollectingKidney Tubules, ProximalMaleMembrane Transport ProteinsMiceMice, Inbred C57BLNephronsPhosphorylationSex CharacteristicsSex FactorsSodium Chloride, DietaryBiomarkersMembrane Transport ProteinsSlc12a1 protein, mouseSlc12a3 protein, mouseSlc9a3 protein, mouseSodium Chloride, DietarySodium-Hydrogen Exchanger 3Solute Carrier Family 12, Member 1Solute Carrier Family 12, Member 3high salt regulationNa, K-ATPasesodium transporter

Identifiers

PMID34613843
PMCPMC8616593
OpenAlexW3204815159

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.