Evidence map›Paper›PMID 34616031›Full record

ReviewHypertension research : official journal of the Japanese Society of Hypertension2022

Regulation of myosin light-chain phosphorylation and its roles in cardiovascular physiology and pathophysiology.

Masaaki Ito, Ryuji Okamoto, Hiromasa Ito, Ye Zhe, Kaoru Dohi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Hypertension research : official journal of the Japanese Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Smooth muscle contractile cytoskeleton in health and disease.Journal of muscle research and cell motility · 2026
    Review
  3. Review
  4. Article
  5. Biomedicines · 2025
    Article
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  7. Article
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  19. Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes viaJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Masaaki ItoDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. mitoka@med.mie-u.ac.jp.
Ryuji OkamotoDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.
Hiromasa ItoDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.
Ye ZheDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.
Kaoru DohiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.
Mie University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulation of muscle contraction is a critical function in the cardiovascular system, and abnormalities may be life-threatening or cause illness. The common basic mechanism in muscle contraction is the interaction between the protein filaments myosin and actin. Although this interaction is primarily regulated by intracellular Ca

Indexed as

Muscle ContractionMyosin Light ChainsCardiovascular Physiological PhenomenaMyosin-Light-Chain PhosphatasePhosphorylationMyosin-Light-Chain PhosphataseMyosin Light ChainsMyosin light chain kinaseMyosin light chain phosphorylationMyosin phosphataseRhoARho-kinase

Identifiers

PMID34616031
OpenAlexW3202751953

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.