ArticleOxidative medicine and cellular longevity2021
Effects of Insomnia on Peptic Ulcer Disease Using Mendelian Randomization.
Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- The relationship between insomnia and multiple gastrointestinal disorders: a Mendelian randomization study.BMC gastroenterology · 2025Article
- Associations Between Dietary Factors, Metabolic Factors, Sleep Disorders, Physical Activity, and the Risk of Multiple Sclerosis: A Univariable and Multivariable Mendelian Randomization Study.Food science & nutrition · 2025Article
- Findings and Methodological Shortcomings of Investigations Concerning the Relationship Between Sleep Duration and Blood Pressure: A Comprehensive Narrative Review.Journal of cardiovascular development and disease · 2025Review
- Effect of Preoperative Sleep Disorders on Postoperative Enteral Nutrition Intolerance in Patients with Digestive Tract Tumors: A Prospective Cohort Study.Nature and science of sleep · 2025Article
- Mendelian randomization studies on the causal relationship between insomnia and disease.Frontiers in medicine · 2025Review
- Study on the relationship between insomnia disorder, PET/CT, and gut microbiota in patients with Alzheimer's disease.Frontiers in neurology · 2025Article
- Long sleep duration and good sleep quality reduced incident peptic ulcer disease in a large Taiwanese population follow-up study.International journal of medical sciences · 2025Article
- Impact of insomnia upon inflammatory digestive diseases and biomarkers: a two-sample mendelian randomization research on Europeans.BMC gastroenterology · 2024Article
- Chronic Inflammation and Age-Related Hearing: Based on Mendelian Randomization.Journal of inflammation research · 2024Article
- Causal associations of white blood cell count and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study.Frontiers in neurology · 2024Article
- Selection of genetic instruments in Mendelian randomisation studies of sleep traits.Sleep medicine · 2023Review
- Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes.BMC medical genomics · 2023Article
- Causal associations of thyroid function and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study.Frontiers in neurology · 2023Article
- Inflammatory markers and the risk of idiopathic sudden sensorineural hearing loss: A Mendelian randomization study.Frontiers in neurology · 2023Article
- Protective Effects of Circulating TIMP3 on Coronary Artery Disease and Myocardial Infarction: A Mendelian Randomization Study.Journal of cardiovascular development and disease · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesObservational studies indicate that insomnia may increase risk of peptic ulcer disease (PUD). Our purpose is to clarify the possible causal relationship between insomnia and PUD by Mendelian randomization analyses.
methodsWe carried out analyses using summary statistics data for genetic variants reported from a GWAS of insomnia (
resultsConventional Mendelian randomization analysis showed clear causality between insomnia and PUD; 1 SD increased insomnia incident was related to a 19% higher risk of PUD (
conclusionsThis Mendelian randomization study suggests insomnia as a causal risk factor for PUD. The potential mechanisms included may be immune and oxidative stress. These findings indicate that improving sleep quality could have substantial health benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.